Month: February 2018

Discovery of 7-Oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine Derivatives as Potent, Orally Available, and Brain-penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors; Analysis of Structure-Kinetic Relationships.

Discovery of 7-Oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine Derivatives as Potent, Orally Available, and Brain-penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors; Analysis of Structure-Kinetic Relationships.

Multiple Sclerosis Literature
Publication date: Feb 27, 2018 We report herein the discovery and optimization of 7-oxo-2,4,5,7-tetrahydro-6H-pyrazolopyridine derivatives as a novel class of brain-penetrating receptor interacting protein 1 (RIP1) kinase inhibitors. Based on ... Read more