Comparable rates of simulator sickness in Huntington’s disease and healthy individuals – Jacobs M, van der Zwaan KF, Hart EP, Groeneveld GJ, Roos RAC.

Comparable rates of simulator sickness in Huntington’s disease and healthy individuals – Jacobs M, van der Zwaan KF, Hart EP, Groeneveld GJ, Roos RAC.

Publication date: Jan 28, 2019

Comparable rates of simulator sickness in Huntington’s disease and healthy individuals – Jacobs M, van der Zwaan KF, Hart EP, Groeneveld GJ, Roos RAC. OBJECTIVE Investigating driving competence with a simulator provides a controlled setting and has a high reproducibility. In addition, there is less risk of physical harm compared to on-road tests. A disadvantage of using simulators is the occurrence of s…

What does the devastation of the opioid epidemic look like on the ground? Jan Rader is the fire chief, first responder, and a nurse in Huntington, West Virginia who describes her community’s reponse to the opiod epidemic.Huntington is a county of 95,000 people which, in 2017, experienced 1831 overdoses, and 183 deaths.Rader describes some innovative programming in her community to deal with substance use disorder which as reached epidemic proportions not only in her county but across the U.S. Editor’s note:I was the executive director of GCASA, the Genesee Council on Alcoholism and Subtance abuse in Genesee and Orleans Counties in Western New York state from 2000 – 2011. I continue to consu…

Effect of ozone exposure on dendritic spines of CA1 pyramidal neurons of the dorsal hippocampus and on object-place recognition memory in rats Publication date: Available online 24 January 2019Source: NeuroscienceAuthor(s): P.C. Bello-Medina, R.A. Prado-AlcalcE1, S. Rivas-ArancibiaAbstractThe growth of many cities has generated an increase in the emission of environmental pollutants. Exposure to these pollutants has been associated with increased mortality worldwide. These pollutants, such as ozone, produce reactive oxygen species (ROS), which cause oxidative stress throughout the body. It has been observed that there is a relationship between chronic oxidative stress and the development of degenerative diseases typical of old age such as amyotrophic lateral…

Publication date: Available online 24 January 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Gabriela Delevati Colpo, Erin Furr Stimming, Antonio Lucio TeixeiraAbstractHuntington’s disease (HD) is an autosomal-dominant neurodegenerative disorder encoding a mutant form of the huntingtin protein (HTT). HD is pathologically characterized by loss of neurons in the striatum and cortex, which leads to progressive motor dysfunction, cognitive decline and behavioral symptoms. Stem cell-based therapy has emerged as a feasible therapeutic approach for the treatment of neurodegenerative diseases and may be effective in all…

Neuroprotective effect of solanesol against 3-nitropropionic acid-induced Huntington ‘s disease-like behavioral, biochemical, and cellular alterations: Restoration of coenzyme-Q10-mediated mitochondrial dysfunction CONCLUSION: In the present research work, SNL (5, 10, and 15 mg/kg p.o.) provided notable neuroprotective effect, which was confirmed by behavioral paradigms and biochemical test. It restored the behavioral and biochemical alteration caused by 3-NP and confirmed the strong neuroprotective mechanism of SNL in 3-NP-intoxicated memory and cognitive abnormalities.

Human Pluripotent Stem Cell-Derived Striatal Interneurons: Differentiation and Maturation In Vitro and in the Rat Brain Publication date: Available online 17 January 2019Source: Stem Cell ReportsAuthor(s): Zoe Noakes, Francesca Keefe, Claudia Tamburini, Claire M. Kelly, Maria Cruz Santos, Stephen B. Dunnett, Adam C. Errington, Meng LiSummaryStriatal interneurons are born in the medial and caudal ganglionic eminences (MGE and CGE) and play an important role in human striatal function and dysfunction in Huntington’s disease and dystonia. MGE/CGE-like neural progenitors have been generated from human pluripotent stem cells (hPSCs) for studying cortical interneuron development and cell therapy for epilepsy and other neurodevelopmental disorders…

A Network Pharmacology-Based Approach to Investigate the Novel TCM Formula against Huntington’s Disease and Validated by Support Vector Machine Model. Authors: Dai W, Chen HY, Chen CY Abstract Several pathways are crucial in Huntington’s disease (HD). Based on the concept of multitargets, network pharmacology-based analysis was employed to find out related proteins in disease network. The network target method aims to find out related mechanism of efficacy substances in rational design way. Traditional Chinese medicine prescriptions would be used for research and development against HD. Virtual screening was performed to obtain drug molecules with high binding capacity from traditional Chinese medicine (TCM) database@Taiwan. Quantitative structure-activity relati…

Huntington Beach, CA -January 15, 2019-Management from Kettenbach LP and Airway Metrics LLC announced today the acquisition by Kettenbach LP of all business assets of Airway Metrics effective end of business February 28, 2019.Airway Metrics LLC has provided an effective product system to assist dentists in determining the correct vertical and protrusive dimensions needed in a bite to produce an optimum airway to manage OSA through dental professionally prescribed and delivered oral sleep appliances.Supported by a large number of experts in the field of Dental Sleep Medicine, Airway Metrics has become an essenti…

Behavioral experimental paradigms for the evaluation of drug’s influence on cognitive functions: Interpretation of associative, spatial/non-spatial and working memory. CONCLUSION: Since the neurodegenerative disorders and dementia has continuously been increasing, wide range of therapeutic targets have been developed at cellular and molecular level. This arise the necessity of screening of these targets in different cognitive behavioral paradigms which reflect their memory enhancing potential. The understanding of behavioral models and involvement of brain structures in cognitive functions highlighted in the present review might be helpful to advance therapeutic interventions. PMID: 30648527 [PubMed – as supplied by publisher]



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