Immunogenicity and therapeutic effects of latency-associated genes in a Mycobacterium tuberculosis reactivation mouse model.

Immunogenicity and therapeutic effects of latency-associated genes in a Mycobacterium tuberculosis reactivation mouse model.

Publication date: Feb 06, 2019

In this study, the MTB latency-associated antigens Rv2660c, Rv1733c, Rv1813c, Rv2628, Rv2029c, Rv2659c were compared regarding their immunogenicity and potential therapeutic effects in an MTB reactivation mouse model. Normal mice or MTB reactivation mice were immunized intramuscularly three times at two-week intervals with saline, plasmid vector pVAX1, M. vaccae vaccine (a commercial inactivated vaccine), rv1813c DNA, rv2628 DNA, rv2029c DNA,rv2659c DNA, rv1733c DNA or rv2660c DNA. The normal mice immunized with rv2628 DNA or rv2659c DNA had low numbers of Th1 cells and a lower ratio of Th1/Th2 immune cells in whole blood (P

Liang, Y., Zhang, X., Bai, X., Yang, Y., Gong, W., Wang, T., Ling, Y., Zhang, J., Wang, L., Wang, J., Li, G., Chen, Y., Chen, X., and Wu, X. Immunogenicity and therapeutic effects of latency-associated genes in a Mycobacterium tuberculosis reactivation mouse model. 04742. 2019 Hum Gene Ther Methods.



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