The polymorphism of SREBF1 gene rs11868035 G/A is associated with susceptibility to Parkinson’s disease in a Chinese population.

The polymorphism of SREBF1 gene rs11868035 G/A is associated with susceptibility to Parkinson’s disease in a Chinese population.

Publication date: Feb 06, 2019

To explore the potential association between the single-nucleotide polymorphism (SNP) of two functional genes (sterol regulatory element binding transcription factor1 [SREBF1] gene rs11868035 and USP25 gene rs2823357) and susceptibility to Parkinson’s disease (PD) in people of Northeast China.

A number of 649 cases of PD from consecutive outpatient and inpatient ward of our hospital were included in this retrospective study, and 355 healthy people were also included as control group. The technique of Kompetitive Allele Specific PCR (KASP) was applied to determine the frequency distribution of genotype and allele gene of rs11868035 and rs2823357 in both groups.

The significant association was observed for SREBF1 gene rs11868035 in G carriers in PD patients. The frequency of GA + GG genotype and G allele in PD group was significantly higher than in control group of SREBF1 gene rs11868035 (p.05).

Polymorphism of SREBF1 gene rs11868035 may increase susceptibility to PD in the northeastern Chinese population, while variant of USP25 gene rs2823357 may have no association with susceptibility to PD in northeastern Chinese. PD patients with G/A variant may worsen their motor and cognitive function disorder.

Lou, F., Li, M., Liu, N., Li, X., Ren, Y., and Luo, X. The polymorphism of SREBF1 gene rs11868035 G/A is associated with susceptibility to Parkinson’s disease in a Chinese population. 19791. 2019 Int J Neurosci.



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