Kappa Opioid Receptor Antagonism for the Tx of AUD and Comorbid PTSD

Kappa Opioid Receptor Antagonism for the Tx of AUD and Comorbid PTSD

Publication date: Feb 25, 2019

Objective: Evaluate the efficacy and physiological effects of sublingual buprenorphine (SL-BUP; Subutex) combined with extended-release injectable naltrexone (XR-NTX; Vivitrol) in the treatment alcohol use disorder of comorbid (AUD) and post-traumatic stress disorder (PTSD)

Concepts Keywords
ADHD Schizoaffective disorder
Alanine Aminotransferase Anxiolytic
Alcohol Substance abuse
Allergic Reaction Alcoholism
Alzheimer Buprenorphine
Aminotransferase Naltrexone
Antianxiety Posttraumatic stress disorder
Antidepressants Opioids
Antipsychotics RTT
Anxiolytics Psychiatric diagnosis
Arrhythmia Chemical compounds
Aspartate Psychiatry
AUD Psychotherapy
Baclofen Surgery
Barrier Method Birth control
Benzodiazepine TBI
Benzodiazepines Dementia
Bipolar AUD PTSD
Birth Control Terminal illness
Blood Pressure Major depressive disorder
Breastfeeding Therapy PTSD
Bronchospasm ADHD
Buprenorphine Bipolar schizophrenia
Caffeine Intrauterine device
Cannabis Treatment
Cardiovascular
Comorbid
Contraceptives
Contraindicate
Dementia
Disulfiram
Double Blind
DSM
ECG
Electrocardiogram
EMDR
Extended Release
Febrile Seizures
Gabapentin
Generic Brand
Hearing Loss
Heart Block
Heart Failure
Hemophilia
Hepatic
Hypersensitivity
Hyperthyroidism
Hypnotics
Illicit Drugs
IM
Informed Consent
Insomnia
Intrauterine Device
Major Depressive Disorder
MINI
Mood Stabilizers
Msec
Myocardial Infarction
Naltrexone
Nicotine
Ohio
Ondansetron
Opioid
Opioids
Placebo
Pregnancy
Protocol
Psychotic
Psychotropic
PTSD
Randomization
Renal Insufficiency
Schizophrenia
Seizures
SL
Stimulants
Sublingual
Substance Abuse
Subutex
Suicide
Symptom
Terminal Illness
Thrombocytopenia
Thyroid Stimulating Hormone
Topiramate
Transdermal
Trauma
Traumatic Brain Injury
TSH
Vital Signs
Vivitrol
Washout

Semantics

Type Source Name
disease MESH PTSD
drug DRUGBANK Buprenorphine
gene UNIPROT COMMD3
pathway BSID Release
drug DRUGBANK Naltrexone
disease MESH alcohol use disorder
disease DOID alcohol use disorder
disease DOID post-traumatic stress disorder
disease MESH men
gene UNIPROT ELL
gene UNIPROT EHD1
disease MESH diagnosis
gene UNIPROT CADPS
gene UNIPROT CAPS
drug DRUGBANK Ethanol
drug DRUGBANK Disulfiram
drug DRUGBANK Acamprosate
drug DRUGBANK Topiramate
drug DRUGBANK Ondansetron
drug DRUGBANK Baclofen
drug DRUGBANK Gabapentin
disease DOID ADHD
drug DRUGBANK Prazosin
drug DRUGBANK Benzodiazepine
disease MESH insomnia
gene UNIPROT ARID1A
gene UNIPROT OPN4
gene UNIPROT NLN
gene UNIPROT OPRM1
disease MESH schizophrenia
disease DOID schizophrenia
disease MESH major depressive disorder
disease DOID major depressive disorder
disease MESH suicide
disease MESH substance use disorder
drug DRUGBANK Caffeine
drug DRUGBANK Nicotine
drug DRUGBANK Medical Cannabis
disease DOID substance abuse
disease MESH seizures
disease MESH febrile seizures
disease MESH renal insufficiency
disease MESH arrhythmia
disease MESH heart failure
disease MESH myocardial infarction
disease DOID myocardial infarction
disease MESH thrombocytopenia
disease DOID thrombocytopenia
disease MESH hemophilia
disease MESH hepatic failure
disease MESH complete hearing loss
disease MESH abnormalities
drug DRUGBANK Thyrotropin alfa
disease MESH hyperthyroidism
disease DOID hyperthyroidism
drug DRUGBANK L-Alanine
disease MESH electrocardiogram
disease MESH allergic reaction
disease MESH bronchospasm
disease DOID bronchospasm
disease DOID hypersensitivity
gene UNIPROT NR4A3
disease MESH dementia
disease DOID dementia
gene UNIPROT NR4A2
gene UNIPROT ALG3

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