Callosal White Matter Abnormalities Linked to Cognitive Impairment in Parkinson Disease

Callosal White Matter Abnormalities Linked to Cognitive Impairment in Parkinson Disease

Publication date: Feb 27, 2019

Findings from a small study suggest that increased mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) in the corpus callosum may be associated with cognitive impairment in patients with Parkinson disease (PD). Findings from the study were published in Neurology.

Patients with PD (n=75) and healthy controls (n=24) who had both diffusion tensor imaging (DTI) and structural magnetic resonance imaging (MRI) brain scans in a prospective study of clinical and neuroimaging markers of PD cognitive impairment were included in the study. The researchers characterized patients as having normal cognition (n=23), mild cognitive impairment (n=35), or dementia (PDD) (n=17), according to the Movement Disorder Society criteria.

In addition, DTI scalar values such as fractional anisotropy (FA), MD, AD, and RD were established for the cortical projections of -5 callosal segments on a midsagittal plane, single slice using a topographically derived parcellation method.” The 5 segments included segment 1 (most anterior), prefrontal cortex; segment 2, premotor and supplementary motor cortex; segment 3, motor cortex; segment 4, sensory cortex; and segment 5 (most posterior), parietal, temporal, and occipital cortex. To examine the associations between cognitive domain z-scores and callosal segment DTI values, the researchers performed linear regression analyses.

Compared with healthy controls, patients with PD had increased AD values in the anterior 3 callosal segments (segment 1: P =.033; segment 2: P =.006; segment 3: P =.002). In group pairwise comparison analyses, patients with PDD had increased MD, AD, and RD values vs patients with PD and normal cognition in segment 1 (all P

Concepts Keywords
Cognition Diffusion tensor imaging
Cognitive Mild cognitive impairment
Cognitive Impairment Brain
Corpus Callosum Frontal lobe
Cortical Cerebrum
Dementia Cerebral cortex
Diffusion Tensor Imaging Corpus callosum
DTI Diffusion MRI
Linear Regression Prefrontal cortex
Magnetic Resonance Imaging MRI
Mild Cognitive Impairment Magnetic resonance imaging
Motor Cortex
MRI Brain Scans
Occipital Cortex
Pairwise Comparison
Posterior Parietal
Sensory Cortex
Supplementary Motor Cortex


Type Source Name
disease MESH Abnormalities
disease MESH Cognitive Impairment
disease MESH Parkinson Disease
disease DOID Parkinson Disease
disease MESH dementia
disease DOID dementia
disease DOID PDD
disease MESH Movement Disorder


Original Article

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