Treatment Strategies and Survival Trends for Anorectal Melanoma: Is it Time for a Change?

Treatment Strategies and Survival Trends for Anorectal Melanoma: Is it Time for a Change?

Publication date: Mar 04, 2019

Immunotherapy advances for the treatment of cutaneous melanoma question its efficacy in treating anorectal mucosal melanoma (ARMM). We aimed to identify the prevalence, current management, and overall survival (OS) for ARMM.

Review of patients with ARMM from 2004 to 2015 National Cancer Database. Factors associated with immunotherapy were identified using multivariable logistic regression. The primary outcome was 2- and 5-year OS. Subgroup analysis by treatment type was performed.

A total of 1331 patients were identified with a significant increase in prevalence (2004: 6.99%, 2015: 10.53%). ARMM patients were older, white, on Medicare, and from the South. The most common treatment was surgery (48.77%), followed by surgery + radiation (11.75%), surgery + immunotherapy (8.68%), and surgery + chemotherapy (8.68%). 16.93% of patients received immunotherapy, with utilization increasing (7.24%: 2004, 21.27%: 2015, p 

Taylor, J.P., Stem, M., Yu, D., Chen, S.Y., Fang, S.H., Gearhart, S.L., Safar, B., and Efron, J.E. Treatment Strategies and Survival Trends for Anorectal Melanoma: Is it Time for a Change? 21848. 2019 World J Surg.

Concepts Keywords
ARMM Chemotherapy
Chemotherapy Radiation
Immunotherapy Radiation therapy
Logistic Regression Immunotherapy
Medicare Branches of biology
Melanoma Health
Radiation Cancer
Melanoma
Medicine
RTT
Immunotherapy
Surgery
Chemotherapy
Radiation

Semantics

Type Source Name
disease DOID Cancer
disease MESH Cancer
disease DOID mucosal melanoma
disease DOID cutaneous melanoma
pathway BSID Melanoma
disease DOID Melanoma
disease MESH Melanoma

Original Article

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