First-in-human clinical study of novel technique to diagnose malignant melanoma via thermal conductivity measurements

First-in-human clinical study of novel technique to diagnose malignant melanoma via thermal conductivity measurements

Publication date: Mar 08, 2019

Here we investigated invasive and non-invasive melanoma patients to detect the threshold of dermal invasion using thermal conductivity measurements of the skin surface.

This device can also be used for a non-invasive and accurate measurement of the effective thermal conductivity of human skin by measuring skin surface temperature response for a short time.

Because skin surface temperature, which is regulated by the local metabolism, and blood perfusion underneath the skin, is a reflection of the physiological state of the human body11, many studies have attempted to apply skin surface temperature information to melanoma diagnostic techniques.

They can be generally separated into two types: a passive method that only measures skin surface temperature9,10, and an active method that measures the temperature response on the skin surface when heating or cooling is applied to enhance or induce thermal contrast12,13,14.

The presence of new blood vessels and the increased blood supply affect the temperature response15, resulting in an increase in the effective thermal conductivity of lesions.

Our method only requires skin temperature data for one minute to determine the effective thermal conductivity of the skin, leading to its ability to distinguish melanoma lesions from healthy skin.

Although we investigated the effective thermal conductivity as a diagnostic tool for skin cancer, the exact pathological mechanisms of the correlation between the effective thermal conductivity and stromal factors of melanoma are still unclear.

Concepts Keywords
Angiogenesis Thermography
Blood Thermography
Blood Vessel Thermal conductivity
Capillary Blood Skin biopsy
Correlation Dysplastic nevus
Dermoscopy Skin cancer
Extracellular Matrix Dermatoscopy
Growth Factors Organ systems
Guard Medicine
Histological RTT
Immunohistochemical Cutaneous conditions
Infrared Melanoma
Keratinocytes Surgery
Lesion Nevus
Local Metabolism Micro invasive melanoma
Lymph Diagnostic malignant melanoma
Malignant Melanoma Skin cancer
Melanoma Malignant melanoma
Modality Surgery melanoma
Nevus Imaging
Perfusion
Precancerous
Progressive
Skin Biopsy
Skin Cancer
Stroma
Stromal
Temperature
Thermal Conductivity
Thermistor
Thermocouple
Thermography
Tumour

Semantics

Type Source Name
disease MESH diagnosis
pathway BSID Melanoma
disease MESH nevus
disease DOID malignant melanoma
disease MESH malignant melanoma
disease MESH skin cancer
drug DRUGBANK Sulodexide
pathway BSID Angiogenesis
disease DOID cancer
disease MESH cancer
disease MESH growth
disease MESH separated
gene UNIPROT LARGE1
gene UNIPROT RXFP2
pathway BSID Metabolism
gene UNIPROT EGR3
disease DOID skin cancer

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