Publication date: Mar 08, 2019
Here we investigated invasive and non-invasive melanoma patients to detect the threshold of dermal invasion using thermal conductivity measurements of the skin surface.
This device can also be used for a non-invasive and accurate measurement of the effective thermal conductivity of human skin by measuring skin surface temperature response for a short time.
Because skin surface temperature, which is regulated by the local metabolism, and blood perfusion underneath the skin, is a reflection of the physiological state of the human body11, many studies have attempted to apply skin surface temperature information to melanoma diagnostic techniques.
They can be generally separated into two types: a passive method that only measures skin surface temperature9,10, and an active method that measures the temperature response on the skin surface when heating or cooling is applied to enhance or induce thermal contrast12,13,14.
The presence of new blood vessels and the increased blood supply affect the temperature response15, resulting in an increase in the effective thermal conductivity of lesions.
Our method only requires skin temperature data for one minute to determine the effective thermal conductivity of the skin, leading to its ability to distinguish melanoma lesions from healthy skin.
Although we investigated the effective thermal conductivity as a diagnostic tool for skin cancer, the exact pathological mechanisms of the correlation between the effective thermal conductivity and stromal factors of melanoma are still unclear.