Innate extracellular vesicles from melanoma patients suppress β-catenin in tumor cells by miRNA-34a

Innate extracellular vesicles from melanoma patients suppress β-catenin in tumor cells by miRNA-34a

Publication date: Mar 07, 2019

Here, we demonstrate that plasma extracellular vesicles (pEVs) of non-tumor origin are persistently increased in untreated and post-excision melanoma patients, exhibiting strong suppressive effects on the proliferation of tumor cells. However, whereas pEV from patients preventing tumor relapse down-regulated β-catenin and blocked tumor cell proliferation in an miR-34a-dependent manner, pEV from metastatic patients lost this ability and stimulated β-catenin-mediated transcription.

Concepts Keywords
Extracellular Vesicles MicroRNA
Immune Mechanism Catenin
Melanoma Metastasis
Metastatic RNA
MiRNA Exosome
PEV Vesicles
Plasma Oncology
Relapse Branches of biology
Resection Years tumor
Transcription Surgery
Tumor
Vesicle
Vesicles

Semantics

Type Source Name
disease MESH melanoma
disease DOID melanoma
pathway BSID Melanoma
disease MESH tumor
disease MESH development
gene UNIPROT IMPACT
disease DOID cancer
gene UNIPROT SLC35G1
gene UNIPROT ADAM10
disease MESH relapse
gene UNIPROT MARCH8
gene UNIPROT MYLIP
gene UNIPROT MLXIP
disease MESH residual cancer

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