First-in-human clinical study of novel technique to diagnose malignant melanoma via thermal conductivity measurements.

First-in-human clinical study of novel technique to diagnose malignant melanoma via thermal conductivity measurements.

Publication date: Mar 07, 2019

Melanoma is an aggressive skin cancer that originates from melanocytes and, especially in the case of early-stage melanoma, is distributed adjacent to the epidermis and superficial dermis. Although early-stage melanoma can be distinguished from benign nevus via a dermoscopy, it is difficult to distinguish invasive melanoma in its early stages from in situ melanoma. Because invasive melanoma must undergo a sentinel lymph node biopsy to be diagnosed, a non-invasive method to detect the micro-invasion of early-stage melanoma is needed for dermato-oncologists. This paper proposes a novel quantitative melanoma identification method based on accurate measurements of thermal conductivity using a pen-shaped device. This method requires skin temperature data for one minute to determine the effective thermal conductivity of the skin, allowing it to distinguish melanoma lesions from healthy skin. Results suggest that effective thermal conductivity was negative for in situ melanoma. However, in accordance with tumour progression, effective thermal conductivity was larger in invasive melanoma. The proposed thermal conductivity measurement is a novel tool that detects the micro-invasion of melanoma.

Open Access PDF

Okabe, T., Fujimura, T., Okajima, J., Kambayashi, Y., Aiba, S., and Maruyama, S. First-in-human clinical study of novel technique to diagnose malignant melanoma via thermal conductivity measurements. 21910. 2019 Sci Rep (9):1.

Concepts Keywords
Benign Melanocytic nevus
Dermis Lentigo maligna
Dermoscopy Thermal conductivity
Epidermis Cancer
Malignant Melanoma Dermatoscopy
Melanocytes RTT
Melanoma Medicine
Nevus Physical sciences
Sci Natural sciences
Temperature Melanoma
Thermal Conductivity Quantitative melanoma
Tumour
Benign nevus
Larger invasive melanoma
Conductivity measurements Melanoma
Melanoma invasive melanoma

Semantics

Type Source Name
pathway BSID Reproduction
gene UNIPROT AICDA
gene UNIPROT ENG
gene UNIPROT FBN1
gene UNIPROT INTU
gene UNIPROT F11R
gene UNIPROT COL9A3
gene UNIPROT COMP
gene UNIPROT COL9A1
gene UNIPROT COL9A2
gene UNIPROT SCN8A
gene UNIPROT EXOG
disease MESH Metastasis
disease DOID Acral Lentiginous Melanoma
drug DRUGBANK Bismuth subgallate
gene UNIPROT KAT5
gene UNIPROT ITFG1
gene UNIPROT TIPRL
gene UNIPROT METTL8
drug DRUGBANK Water
gene UNIPROT TNMD
gene UNIPROT CYLD
drug DRUGBANK Tretamine
gene UNIPROT PLEKHG5
gene UNIPROT EGR3
gene UNIPROT MAL
gene UNIPROT MRTFA
gene UNIPROT TIRAP
pathway BSID Angiogenesis
disease MESH separated
gene UNIPROT LARGE1
gene UNIPROT RXFP2
gene UNIPROT DYRK3
gene UNIPROT IK
pathway BSID Metabolism
gene UNIPROT TBPL1
disease MESH growth
gene UNIPROT DEPP1
gene UNIPROT GOPC
gene UNIPROT RAB8A
disease MESH diagnosis
drug DRUGBANK Coenzyme M
gene UNIPROT PUM3
gene UNIPROT TSPAN33
gene UNIPROT PCSK1N
disease MESH nevus
disease DOID skin cancer
disease MESH skin cancer
pathway BSID Melanoma
disease DOID malignant melanoma
disease MESH malignant melanoma

Similar

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *