Alemtuzumab as rescue therapy in case of multiple sclerosis rebound following Natalizumab break: Clinical case and literature review.

Alemtuzumab as rescue therapy in case of multiple sclerosis rebound following Natalizumab break: Clinical case and literature review.

Publication date: Mar 05, 2019

Natalizumab break exposes multiple sclerosis (MS) patients to a high risk of disease reactivation or rebound, whose prevention and treatment constitute a clinical challenge.

We describe a dramatic case of MS rebound, characterized by the development of severe neurological and psychiatric symptoms, following natalizumab break. Alemtuzumab rapidly and completely suppressed brain inflammation as demonstrated by clinical and radiological findings.

Our case further adds to the available literature evidence on Alemtuzumab as first-choice rescue therapy following Natalizumab discontinuation.

Federle, L., Puthenparampil, M., Stenta, G., Paolo, G., and Francesco, P. Alemtuzumab as rescue therapy in case of multiple sclerosis rebound following Natalizumab break: Clinical case and literature review. 17483. 2019 Mult Scler Relat Disord (30):

Concepts Keywords
Alemtuzumab Medicine
Brain Inflammation Multiple sclerosis
Multiple Sclerosis Alemtuzumab
Natalizumab Immunology
Neurological Natalizumab
Medical specialties
Immunosuppressants
Monoclonal antibodies
MS
Brain inflammation

Semantics

Type Source Name
disease MESH brain inflammation
disease MESH development
drug DRUGBANK Natalizumab
disease DOID multiple sclerosis
disease MESH multiple sclerosis
drug DRUGBANK Alemtuzumab

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