Molecular subtyping of bladder cancer: current trends and future directions in 2019.

Molecular subtyping of bladder cancer: current trends and future directions in 2019.

Publication date: Mar 06, 2019

Personalized medicine portends a future where patients receive therapy based on mutational and gene expression profiles intrinsic to their tumor. Recent advances in molecular subtyping of tumors have pushed us closer to using patient-specific data to guide therapy. The purpose of this review is to understand how these advances may be used to understand tumor development and direct therapeutic regimens clinically.

Multiple reports have identified specific molecular subtypes present in bladder cancer. A variety of classification schemes are currently being suggested based on different groups observations on gene expression, mutational profile, and histological variability. Notably, recent novel findings indicate standard of care with neoadjuvant platinum-based chemotherapy effectively removes the basal subtype specifically, indicating clinical data largely supports the use of molecular subtyping as a way to treat tumors.

Although varied classifications are present in the field currently, more work is required to truly define which subtypes are responsive to specific therapies. Current data supports the idea that molecular subtyping will benefit patients; however, these data also argue in favor of combinatorial therapy and molecular profiling throughout treatment.

Smelser, W.W., Woolbright, B.L., and Taylor, J.A. Molecular subtyping of bladder cancer: current trends and future directions in 2019. 04195. 2019 Curr Opin Urol.

Concepts Keywords
Basal Chemotherapy
Bladder Cancer Chemotherapy
Chemotherapy Type theory
Combinatorial Therapy
Histological Subtyping
Neoadjuvant Object-oriented programming
Platinum Oncology
Subtyping Cancer treatments
Tumor Medicine
Health
Chemotherapy
Subtyping bladder cancer

Semantics

Type Source Name
drug DRUGBANK Platinum
disease MESH Multiple
disease MESH development
disease MESH tumor
pathway BSID Gene Expression
pathway BSID Bladder cancer
pathway BSID Bladder Cancer
disease DOID bladder cancer
disease MESH bladder cancer

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