Cerebrospinal fluid biomarkers for predicting development of multiple sclerosis in acute optic neuritis: a population-based prospective cohort study.

Cerebrospinal fluid biomarkers for predicting development of multiple sclerosis in acute optic neuritis: a population-based prospective cohort study.

Publication date: Mar 11, 2019

Long-term outcome in multiple sclerosis (MS) depends on early treatment. In patients with acute optic neuritis (ON), an early inflammatory event, we investigated markers in cerebrospinal fluid (CSF), which may predict a diagnosis of MS.

Forty patients with acute ON were recruited in a prospective population-based cohort with median 29 months (range 19-41) of follow-up. Paired CSF and serum samples were taken within 14 days (range 2-38), prior to treatment. Prospectively, 16/40 patients were by a uniform algorithm diagnosed with MS (MS-ON) and 24 patients continued to manifest isolated ON (ION) during follow-up. Levels of cytokines and neurofilament light chain (NF-L) were measured at the onset of acute ON and compared to healthy controls (HC). Significance levels were corrected for multiple comparisons (“q”). The predictive value of biomarkers was determined with multivariable prediction models using nomograms.

CSF TNF-α, IL-10, and CXCL13 levels were increased in MS-ON compared to those in ION patients (q = 0.021, 0.004, and 0.0006, respectively). MS-ON patients had increased CSF pleocytosis, IgG indices, and oligoclonal bands (OCBs) compared to ION (q = 0.0007, q = 0.0058, and q = 0.0021, respectively). CSF levels of IL-10, TNF-a, IL-17A, and CXCL13 in MS-ON patients correlated with leukocyte counts (r > 0.69 and p  0.55, p 

Olesen, M.N., Soelberg, K., Debrabant, B., Nilsson, A.C., Lillevang, S.T., Grauslund, J., , Brandslund, Madsen, J.S., Paul, F., Smith, T.J., Jarius, S., and Asgari, N. Cerebrospinal fluid biomarkers for predicting development of multiple sclerosis in acute optic neuritis: a population-based prospective cohort study. 17497. 2019 J Neuroinflammation (16):1.

Concepts Keywords
Algorithm Multiple sclerosis
Biomarkers Cerebrospinal fluid
Cerebrospinal Fluid Optic neuritis
Cohort Oligoclonal band
Cytokines Immunology
IgG Autoimmune diseases
Leukocyte Neurology
Multiple Comparisons Biomarkers
Multiple Sclerosis Clinical medicine
Neurofilament Medical specialties
Nomograms Medicine
Optic Neuritis Multiple sclerosis
Prospective Cohort Study MS
Serum Early inflammatory event
TNF Uniform algorithm

Semantics

Type Source Name
disease MESH Inflammation
gene UNIPROT IL17A
disease MESH pleocytosis
gene UNIPROT CXCL13
gene UNIPROT IL10
drug DRUGBANK Interleukin-10
gene UNIPROT TNF
disease MESH multiple
gene UNIPROT NEFL
gene UNIPROT TNFSF14
disease MESH diagnosis
gene UNIPROT LAMC2
gene UNIPROT CSF2
disease DOID optic neuritis
disease MESH optic neuritis
disease DOID multiple sclerosis
disease MESH multiple sclerosis
disease MESH development

Original Article

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