New Strategy Targets Parkinson’s by Improving Dopamine Metabolism, Study Reports

New Strategy Targets Parkinson’s by Improving Dopamine Metabolism, Study Reports

Publication date: Mar 13, 2019

In contrast to what was previously believed, a key protein implicated in Parkinson’s disease – called Nurr1 – can be modulated using naturally existing molecules or engineered small molecules to restore dopamine production in brain cells, according to a study.

Conducted by researchers from the University of California San Francisco (UCSF), the new study provides evidence that the activation of Nurr1 may represent a viable strategy to slow or halt the progression of Parkinson’s disease.

Preclinical data has shown that elevating the levels of Nurr1 can reduce inflammation and improve the survival of neurons, while reduction of the protein leads to motor symptoms in mice similar to those seen in Parkinson’s disease.

Using experimental cell and fish models, the researchers tested the potential of DHI to enhance Nurr1’s activity.

In addition, DHI-triggered activation of Nurr1 led to increased production of dopamine transporters in fish, including VMAT2 – a protein that regulates the packaging and release of dopamine into the synapse, the junction between two nerve cells that allow them to communicate.

Concepts Keywords
Brain Neuron
California Dopamine transporter
Dihydroxyindole Vesicular monoamine transporter
DOPA Nur
Dopamine Neurotransmitter transporters
Dopaminergic Transcription factors
Endogenous Branches of biology
England Intracellular receptors
Fish Dopamine
Inflammation Amphetamine
Metabolite Inflammation
Molecule
Nerve
Neurons
Nuclear Receptor
Nucleus
Parkinson
PhD
Protein
San Francisco
Small Molecule
Synapse
Transcription
UCSF
Vesicles
VMAT2

Semantics

Type Source Name
pathway BSID Dopamine metabolism
gene UNIPROT NR4A2
drug DRUGBANK Dopamine
gene UNIPROT NAA50
disease MESH development
disease MESH inflammation
gene UNIPROT SH3PXD2A
gene UNIPROT SMIM10L2B
gene UNIPROT SMIM10L2A
gene UNIPROT SLC18A2
pathway BSID Release
drug DRUGBANK Levodopa
gene UNIPROT THOP1
gene UNIPROT PDC

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