BASKET Trials: Biomarker Driven Drug Development

BASKET Trials: Biomarker Driven Drug Development

Publication date: Mar 13, 2019

Presented At:

LabRoots – Drug Discovery Virtual Event 2019

Presented By:

Shivaani Kummar, MD, FACP – Professor of Medicine (Oncology) and of Radiology (Molecular Imaging Program at Stanford), Director Phase I Clinical Research, Director, Translational Oncology Program, Stanford University

Speaker Biography:

Dr. Shivaani Kummar is a medical oncologist who specializes in early phase clinical drug development. She is Professor of Medicine and Director of the Phase I Clinical Research, Medical Oncology, and Translational Oncology Programs at Stanford University. She trained in Internal Medicine at Emory University in Atlanta, Georgia, and then pursued her fellowship training at the National Institutes of Health in Medical Oncology and Hematology. She then became Assistant Professor of Medicine at Yale Cancer Center, Yale University School of Medicine, where she developed in an interest in developmental therapeutics.

Webinar:

BASKET Trials: Biomarker Driven Drug Development

Webinar Abstract:

Dramatic responses observed with targeted agents in the ‘right’ genomic context have fueled large scale sequencing efforts to identify ‘effective’ treatments for a given patient. In order to expeditiously evaluate a targeted agent against a potential ‘driver’ genetic aberration, so-called Basket trials are conducted. Basket trials enroll patients with multiple tumor types that carry a common genetic aberration and evaluate a single targeted treatment regimen. I will discuss the rationale, design, and challenges in conducting Basket trials.

Learning Objectives:

1. Learn about when to consider conducting a Basket trial and how to design it

2. Learn about the promises and challenges of identifying patients based on genomic aberrations

Earn PACE/CME Credits:

1. Make sure you’re a registered member of LabRoots (https://www.labroots.com/virtual-event/drug-discovery-2019)

2. Watch the webinar on YouTube above or on the LabRoots Website (https://www.labroots.com/virtual-event/drug-discovery-2019)

3. Click Here to get your PACE (Expiration date – February 27, 2021 01:30 PM) – https://www.labroots.com/credit/pace-credits/3222/third-party

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Concepts Keywords
Aberration Agents tumor
Ado Dollars explosion cancer
Agnostic Infantile fibra sarcoma
Amputation Melanoma
Atlanta Mutation positive melanoma
Beer Strom ER tumor
Biomarker Squamous carcinoma
Biopsies Well tumor matter
Breast Cancer Imaging
Caliph Areas tumor
Cancer Infantile fibers sarcoma
Carcinoma Basket solid tumors
Cevennes Agent tumors
Chester Largest comprehensive tumor
Code Word Rest tumor
Cohort Actionable tumor
Continuing Education Pain
Control Group Targets treatment cancer
Cryogenic Positive breast cancer
Drug Development Thyroid sarcoma
Drug Discovery Combination chemotherapy
Egypt Leg amputation
Facebook Surgery
FACP Medicine
FDA Clinical medicine
Finn Health
French RTT
Frequency Antineoplastic drugs
Fusion Partners Oncology
Gastric Cancer Cancer
Genesis Targeted therapy
Genetic Melanoma
Genome Chemotherapy
Genomic Sequencing Draft:Personalized Onco-genomics
Georgia Drug discovery
Hematology Chemotherapy
Histological Ado
Histology Drug development
Hormone
Humors
Imprint
Incidence
Infusion
Instagram
Interventional Radiology
Kindness
LinkedIn
Liver
Lung
Lung Cancer
Melanoma
Membrane
Memory
Modulation
Molecular Imaging
Morava
Mutation
NPR
Nun
Oncologist
Oncology
Pain
Paradigm
Paradigm Shift
Perma
Physician
Pinterest
Point Mutations
Prime
Radiology
Raffi
Raffle
Receptor
Roma
Sampled
Sarcoma
Scientific Hypothesis
Sequencing
Shivani
SnapChat
Social Networking Website
Somatic
Squamous Carcinoma
Stanford
Stanford University
Sympathetic Nervous System
Targeted Treatments
Thyroid
Trance
Tumor
Webinar
Yale
YouTube

Semantics

Type Source Name
drug DRUGBANK Coenzyme M
gene UNIPROT FURIN
disease MESH multiple
gene UNIPROT LARGE1
disease DOID Cancer
disease MESH Cancer
disease MESH Development

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