Complex I syndrome in striatum and frontal cortex in a rat model of Parkinson disease.

Complex I syndrome in striatum and frontal cortex in a rat model of Parkinson disease.

Publication date: Mar 09, 2019

Mitochondrial dysfunction named complex I syndrome was observed in striatum mitochondria of rotenone treated rats (2 mg rotenone/kg, i. p., for 30 or 60 days) in an animal model of Parkinson disease. After 60 days of rotenone treatment, the animals showed: (a) 6-fold increased bradykinesia and 60% decreased locomotor activity; (b) 35-34% decreases in striatum O uptake and in state 3 mitochondrial respiration with malate-glutamate as substrate; (c) 43-57% diminished striatum complex I activity with 60-71% decreased striatum mitochondrial NOS activity, determined both as biochemical activity and as functional activity (by the NO inhibition of active respiration); (d) 34-40% increased rates of mitochondrial O and HO productions and 36-46% increased contents of the products of phospholipid peroxidation and of protein oxidation; and (e) 24% decreased striatum mitochondrial content, likely associated to decreased NO-dependent mitochondrial biogenesis. Intermediate values were observed after 30 days of rotenone treatment. Frontal cortex tissue and mitochondria showed similar but less marked changes. Rotenone-treated rats showed mitochondrial complex I syndrome associated with cellular oxidative stress in the dopaminergic brain areas of striatum and frontal cortex, a fact that describes the high sensitivity of mitochondrial complex I to inactivation by oxidative reactions.

Valdez, L.B., Zaobornyj, T., Bandez, M.J., L’opez-Cepero, J.M., Boveris, A., and Navarro, A. Complex I syndrome in striatum and frontal cortex in a rat model of Parkinson disease. 20101. 2019 Free Radic Biol Med.

Concepts Keywords
Biochemical Striatum
Bradykinesia Respiratory complex I
Brain Mitochondrion
Dopaminergic Rotenone
Frontal Cortex Isoflavones
Glutamate Basal ganglia
Locomotor Activity Integral membrane proteins
Malate Cerebrum
Mitochondria Cellular respiration
Mitochondrial Enzymes
NOS Branches of biology
Oxidation Brain
Oxidative Stress Bradykinesia
Parkinson Disease Mitochondrial complex syndrome
Phospholipid Contents products
Respiration
Rotenone
Striatum
Substrate
Syndrome

Semantics

Type Source Name
gene UNIPROT SSRP1
pathway BSID Oxidative Stress
disease MESH oxidative stress
pathway BSID Mitochondrial biogenesis
disease MESH bradykinesia
drug DRUGBANK Rotenone
disease DOID Parkinson disease
disease MESH Parkinson disease
disease DOID syndrome
disease MESH syndrome

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