Publication date: Mar 13, 2019
LabRoots – Drug Discovery Virtual Event 2019
Khyati Shah, PhD – Post Doctoral Research Scholar at University of California, San Francisco
Khyati Shah received her Ph.D. in Molecular Pharmacology from the University of the Pacific, Stockton, California. Her graduate research was completed in the lab of Jesika Faridi, Ph.D. Her work focused on the investigation of the mechanism of Akt induced tamoxifen resistance in breast cancer. Currently, Khyati is the research fellow in Bandyopadhyay Lab since 2015. Her project involves investigation of the mechanism of resistance to targeted and immuno-therapy using systems biology approach. She has three-first author publications in the reputed peer-reviewed journals and 7 oral and 15 poster talks on the use of systemic genomics and proteomic approach to design rational combination therapy and to increase the durability of therapeutic response.
Developing Precision Combination Therapies to Overcome Evolution of Therapeutic Resistance
Recent clinical successes in cancer genome-inspired personalized medicine have been a major breakthrough in drug discovery. However, 98% of the patients have an incomplete therapeutic response. These patients with residual disease, progress upon therapy and develop acquired resistance and derive limited survival. Tumors are proficient at developing resistant to therapies, and the molecular mechanisms of therapeutic resistance are critical to pinpointing strategies to prevent these escape routes and to obtain long-lasting clinical responses. Using clinical specimen of disease progression, a majority of genetic alterations have been characterized and shown to co-exists upon acquired resistance, hence targeting single genetic driver would be futile to combat poly-clonal resistance. Therefore, there is an increasing need to find a targetable approach to prevent the evolution of resistance and yield a complete therapeutic response to abrogate the residual disease.
1. Define the limitation of therapeutic resistance in drug discovery
2. Design the strategy to overcome resistance
3. Identify basis of resistance evolution
Earn PACE/CME Credits:
1. Make sure you’re a registered member of LabRoots (https://www.labroots.com/virtual-event/drug-discovery-2019)
2. Watch the webinar on YouTube above or on the LabRoots Website (https://www.labroots.com/virtual-event/drug-discovery-2019)
3. Click Here to get your PACE (Expiration date – February 27, 2021 10:30 AM)- https://www.labroots.com/credit/pace-credits/3241/third-party
LabRoots on Social: