Distinct clinicopathological and prognostic features of thin nodular primary melanomas: an international study from 17 centers.

Distinct clinicopathological and prognostic features of thin nodular primary melanomas: an international study from 17 centers.

Publication date: Mar 13, 2019

Nodular melanoma (NM) is more likely to be fatal compared to other melanoma subtypes, an effect attributed to its greater Breslow thickness.

Clinicopathological features of NM and superficial spreading melanoma (SSM) diagnosed in 17 centers in Europe (n = 15), USA and Australia between 2006 and 2015, were analyzed by multivariate logistic regression analysis, with emphasis in thin (T1 ≤ 1.0 mm) melanomas. Cox analysis assessed melanoma-specific survival (MSS). All statistical tests were two-sided.

In all, 20,132 melanomas (NM: 5,062, SSM: 15,070) were included. Compared to T1 SSM, T1 NM was less likely to have regression (OR: 0.46, 95% CI: 0.29-0.72) or nevus remnants histologically (OR: 0.60, 95% CI: 0.42-0.85), and more likely to have mitoses (OR: 1.97, 95% CI: 1.33-2.93) and regional metastasis (OR: 1.77, 95% CI: 1.02-3.05). T1 NM had a higher mitotic rate than T1 SSM (adjusted geometric mean 2.2 [95% CI:1.9-2.4] vs 1.6 [95% CI:1.5-1.7] per mm2, p 

Dessinioti, C., Dimou, N., Geller, A.C., Stergiopoulou, A., Lo, S., Keim, U., Gershenwald, J.E., Haydu, L.E., Ribero, S., Quaglino, P., Puig, S., Malvehy, J., Kandolf-Sekulovic, L., Radevic, T., Kaufmann, R., Meister, L., Nagore, E., , Traves, Champsas, G.G., Plaka, M., Dreno, B., Varey, E., Ramirez, D.M., Dummer, R., Mangana, J., Hauschild, A., Egberts, F., Peris, K., Del Regno, L., Forsea, A.M., Zurac, S.A., Vieira, R., Brinca, A., , Zalaudek, Deinlein, T., Linos, E., Evangelou, E., Thompson, J.F., Scolyer, R.A., Garbe, C., and Stratigos, A.J. Distinct clinicopathological and prognostic features of thin nodular primary melanomas: an international study from 17 centers. 21952. 2019 J Natl Cancer Inst.

Concepts Keywords
Australia SSM
Europe Breslow’s depth
Histologically Nodular melanoma
Logistic Regression Superficial spreading melanoma
Melanoma Health
Melanomas Neoplasms
Metastasis Melanoma
Mitoses Medicine
Mitotic
Multivariate
Nevus
Regression

Semantics

Type Source Name
disease DOID Cutaneous melanoma
gene UNIPROT PNMA2
disease MESH metastasis
disease MESH nevus
gene UNIPROT SIL1
gene UNIPROT COX5A
gene UNIPROT COX8A
gene UNIPROT CPOX
disease DOID melanoma
pathway BSID Melanoma
disease MESH melanomas
drug DRUGBANK Methyprylon

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