Dynamic C-PiB PET shows cerebrospinal fluid flow alterations in Alzheimer’s disease and multiple sclerosis.

Dynamic C-PiB PET shows cerebrospinal fluid flow alterations in Alzheimer’s disease and multiple sclerosis.

Publication date: Mar 08, 2019

Cerebrospinal fluid (CSF) plays an important role in the clearance of solutes and maintenance of brain homeostasis. C-PiB PET was recently proposed as a tool for detection of CSF clearance alterations in Alzheimer’s disease. The current study seeks to investigate the magnitude of C-PiB PET signal in the lateral ventricles of an independent group of Alzheimer’s and mild cognitive impairment subjects. We have also evaluated multiple sclerosis as a model of disease with CSF clearance alterations without amyloid-beta tissue accumulation. Methods: A set of Alzheimer’s and mild cognitive impairment subjects and a set of multiple sclerosis subjects with matched healthy controls underwent MRI and dynamic C-PiB PET. Manual lateral ventricle regions of interest were generated from MRI data. PET data was analysed using a simplified reference tissue model with cerebellum or a supervised reference region, for the Alzheimer’s and multiple sclerosis datasets, respectively. Magnitude of C-PiB signal in the lateral ventricles was calculated as area under curve from 35 to 80 minutes and standard uptake value ratio (SUVR) from 50 to 70 minutes. Compartmental modelling analysis was performed on a separate dataset containing Alzheimer’s and matched healthy control data with an arterial input function to further understand the kinetics of the lateral ventricular C-PiB signal. Results: Analysis of variance revealed significant group differences in lateral ventricular SUVR across the Alzheimer’s, mild cognitive impairment, and healthy control groups (P = 0.004). Additional pairwise comparisons revealed significantly lower lateral ventricular SUVR in Alzheimer’s compared to healthy controls (p

Schubert, J.J., Veronese, M., Marchitelli, L., Bodini, B., Tonietto, M., Stankoff, B., Brooks, D.J., Bertoldo, A., Edison, P., and Turkheimer, F. Dynamic C-PiB PET shows cerebrospinal fluid flow alterations in Alzheimer’s disease and multiple sclerosis. 17508. 2019 J Nucl Med.

Concepts Keywords
Alzheimer MRI
Amyloid Beta Mild cognitive impairment
Brain Ventricular system
Cerebellum Glymphatic system
Cerebrospinal Fluid Cerebrospinal fluid
Homeostasis RTT
Kinetics Alzheimer’s disease
Lateral Ventricle Learning disabilities
Lateral Ventricles Organ systems
Magnitude Psychiatric diagnosis
Mild Cognitive Impairment Cognitive disorders
MRI Neuroscience
Multiple Sclerosis Branches of biology
Pairwise Comparisons Mild cognitive impairment
PET Multiple sclerosis
Solutes Disease
Variance
Ventricular

Semantics

Type Source Name
gene UNIPROT CYREN
gene UNIPROT SET
disease MESH mild cognitive impairment
gene UNIPROT LAMC2
gene UNIPROT CSF2
disease DOID multiple sclerosis
disease MESH multiple sclerosis

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