Evaluating Biomarkers for Response to Neoadjuvant Immune Checkpoint Blockade..

Evaluating Biomarkers for Response to Neoadjuvant Immune Checkpoint Blockade..

Publication date: Mar 13, 2019

Presented At:

LabRoots – Drug Discovery Virtual Event 2019

Presented By:

Sarah Warren, PhD – Director, Advanced Applications, NanoString

Speaker Biography:

Sarah Warren is the director of advanced applications at NanoString and leads the early immuno-oncology research program. Prior to joining NanoString, she founded and ran Oncofactor Corp, a biotech focused on discovery of novel immune checkpoint inhibitors and development of therapeutics to block their activity. She has a PhD in immunology from the University of Washington and undergraduate degrees in biochemistry and English from Iowa State University.

Webinar:

Evaluating Biomarkers for Response to Neoadjuvant Immune Checkpoint Blockade in Melanoma

Webinar Abstract:

Surgery is the first line of treatment for Stage III melanoma. Often adjuvant therapy is administered post-surgery, which can include weeks of radiation, chemotherapy, targeted drug therapy, or immunotherapy. Previous preclinical studies suggest that treatment with neoadjuvant immune checkpoint blockade may lead to increased survival compared to adjuvant treatment1. This webinar will cover recent data from parallel but independent clinical trials explored the efficacy of anti-PD-1 and/or anti-CLTA4 combination immunotherapy plus surgery in patients with early stage melanoma2,3.

FOR RESEARCH USE ONLY. Not for use in diagnostic procedures.

Learning Objectives:

1. Gain an appreciation for how multiplexed spatial profiling via GeoMx can aid in tumor characterization

2. Understand how GeoMx profiling was used in the 2 studies presented to identify biomarkers of response to immunotherapy and complement other molecular profiling strategies

Earn PACE/CME Credits:

1. Make sure you’re a registered member of LabRoots (https://www.labroots.com/virtual-event/drug-discovery-2019)

2. Watch the webinar on YouTube above or on the LabRoots Website (https://www.labroots.com/virtual-event/drug-discovery-2019)

3. Click Here to get your PACE (Expiration date – February 27, 2021 12:00 PM) – https://www.labroots.com/credit/pace-credits/3269/third-party

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Concepts Keywords
Acid Ado
Adjuvant DSP
Adjuvant Therapy Chemotherapy
Ado Drug discovery
Allah Antibodies
Antibodies Radiation
Antibody Cancer immunotherapy
Art Therapy Melanoma
Asset Biomarker
Att Immunotherapy
Attachment Therapy Checkpoint inhibitor
Bicycle Cancer treatments
Binary Data Cell biology
Biochemistry Immune system
Biomarkers Clinical medicine
Biopsies Branches of biology
Biotech Medicine
Blockade Adjuvant therapy
Blood Drug therapy
Bull Immunotherapy surgery
Cereal Art therapy
Chemistry Radiation
Chemotherapy Immunotherapy
Clinical Trials Surgery
Cocktail Chemotherapy
Complement Response tumor
Conjugated Metastases
Continuing Education Neck tumor melanoma
Digital Recurrence tumor
Dio Immunotherapy tumor
DNA Marcellin inflammation inflammation
Drug Discovery Bull tumor
Drug Therapy Areas tumor
DSP Melanoma
Dynamic Range Tumor inflammation
Ebola Signature inflammation
Ery Immune status tumors
Expression Profiling Strain
Facebook Regions tumors
Fish Progeria
Fluorescent Pre treatment tumor
Flux Thie imaging agents
Globulin
Graph
Immune Checkpoint Blockade
Immune System
Immunity
Immunology
Immunotherapy
Inflammation
Ing
Instagram
Iowa University
Irony
ISS
Khun
Lennier
Liberalism
LinkedIn
Linker
Melanoma
Melun
Merck
Metastases
Metastatic
Microscope
Multiplexed
Munich
Mutation
Mystic
Nana
Nature
Neoadjuvant
Netherlands
Omagh
Oncology
Outline
PhD
Pimple
Pinterest
Plex
Polygon
Ppm
Prize
Radiation
Regiment
Regression
Relapse
Relax
Simple Interest
SnapChat
Soul
Spatial Resolution
Thes
Tonsils
Toxicity
Transcription
Tumor
Vaccine
Washington
Webinar
Workflow
YouTube

Semantics

Type Source Name
drug DRUGBANK Coenzyme M
gene UNIPROT FURIN
disease MESH tumor
gene UNIPROT AICDA
gene UNIPROT TBATA
gene UNIPROT ALG3
gene UNIPROT NR4A2
gene UNIPROT PDCD1
gene UNIPROT RPL17
gene UNIPROT SLC35G1
pathway BSID Melanoma
disease DOID Melanoma
disease MESH Melanoma
disease MESH development
gene UNIPROT RAN
drug DRUGBANK Ranitidine
gene UNIPROT PDC

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