Metal Exposure Tied to Increased Risk of Parkinson’s Disease Symptoms

Metal Exposure Tied to Increased Risk of Parkinson’s Disease Symptoms

Publication date: Mar 14, 2019

Too much exposure to metals such as manganese can lead to the onset of Parkinson’s disease symptoms, reports a new study.

Kanthasamy said the findings could lead to earlier detection of the disease and better outcomes for patients. Kanthasamy said small amounts of manganese are necessary for the proper functioning of the human body, but too much exposure has been linked with neurological symptoms much like those experienced by patients with Parkinson’s Disease.

The study found welders exposed to manganese had increased misfolded alpha-synuclein serum content, meaning the welders are at a higher risk for developing Parkinson’s symptoms, Kanthasamy said. The research could contribute to a new assay, or medical test, to detect the presence of misfolded alpha-synuclein proteins.

Concepts Keywords
Alloy Alpha
Assay Neurotoxin
Biomedical Neurodegeneration
Blood Serum Alpha-synuclein
Brain Manganese
Eurekalert Neurological disorders
Inflammation Peripheral membrane proteins
Iowa Physical sciences
Manganese Chemistry
Misfolding Branches of biology
Neurodegenerative Inflammation
Neurological Progression disease
Neurological Disorders
Parkinson
Protein
Serum
Vesicles
Veterinary

Semantics

Type Source Name
gene UNIPROT ITGBL1
drug DRUGBANK Manganese
drug DRUGBANK Tropicamide
disease MESH neurological disorders
gene UNIPROT SET
disease MESH inflammation

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