Organoid models for translational pancreatic cancer research.

Organoid models for translational pancreatic cancer research.

Publication date: Mar 04, 2019

Despite recent advances in the treatment of cancer, pancreatic ductal adenocarcinoma (PDAC) still retains the worst survival rate of common malignancies. Late diagnosis and lack of curative therapeutic options are the most pressing clinical problems for this disease. Therefore, there is a need for patient models and biomarkers that can be applied in the clinic to identify the most effective therapy for a patient. Pancreatic ductal organoids are ex-vivo models of PDAC that can be established from very small biopsies, enabling the study of localized, advanced, and metastatic patients. Organoids models have been applied to pancreatic cancer research and offer a promising platform for precision medicine approaches.

Tiriac, H., Plenker, D., Baker, L.A., and Tuveson, D.A. Organoid models for translational pancreatic cancer research. 04219. 2019 Curr Opin Genet Dev (54):

Concepts Keywords
Biomarkers David Tuveson
Cancer Pancreas
Malignancies Pancreatic duct
Metastatic Pancreatic cancer
Pancreatic Ductal Adenocarcinoma Organoid
PDAC Branches of biology
Stem cells


Type Source Name
disease MESH diagnosis
disease MESH malignancies
pathway BSID Pancreatic cancer
disease DOID pancreatic cancer
disease MESH pancreatic cancer


Original Article

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