Precision exercise medicine: understanding exercise response variability.

Precision exercise medicine: understanding exercise response variability.

Publication date: Mar 12, 2019

There is evidence from human twin and family studies as well as mouse and rat selection experiments that there are considerable interindividual differences in the response of cardiorespiratory fitness (CRF) and other cardiometabolic traits to a given exercise programme dose. We developed this consensus statement on exercise response variability following a symposium dedicated to this topic. There is strong evidence from both animal and human studies that exercise training doses lead to variable responses. A genetic component contributes to exercise training response variability.In this consensus statement, we (1) briefly review the literature on exercise response variability and the various sources of variations in CRF response to an exercise programme, (2) introduce the key research designs and corresponding statistical models with an emphasis on randomised controlled designs with or without multiple pretests and post-tests, crossover designs and repeated measures designs, (3) discuss advantages and disadvantages of multiple methods of categorising exercise response levels-a topic that is of particular interest for personalised exercise medicine and (4) outline approaches that may identify determinants and modifiers of CRF exercise response. We also summarise gaps in knowledge and recommend future research to better understand exercise response variability.

Ross, R., Goodpaster, B.H., Koch, L.G., Sarzynski, M.A., Kohrt, W.M., Johannsen, N.M., Skinner, J.S., Castro, A., Irving, B.A., Noland, R.C., Sparks, L.M., Spielmann, G., Day, A.G., Pitsch, W., Hopkins, W.G., and Bouchard, C. Precision exercise medicine: understanding exercise response variability. 04212. 2019 Br J Sports Med.

Concepts Keywords
Crossover Goodpaster
Genetic Exercise
Medicine Physical fitness
Outline Cardiovascular physiology
Cardiorespiratory fitness
Respiratory physiology


Type Source Name
drug DRUGBANK Tropicamide
disease MESH multiple
disease DOID CRF
drug DRUGBANK Corticorelin


Original Article

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