Primary malignant melanoma of the esophagus: A retrospective analysis of clinical features, management, and survival of 76 patients.

Primary malignant melanoma of the esophagus: A retrospective analysis of clinical features, management, and survival of 76 patients.

Publication date: Mar 12, 2019

Primary malignant melanoma of the esophagus (PMME) is rare. Patients with advanced melanoma of esophageal origin tend to have lower response rates to traditional therapies than those with other melanomas. We report our experience of 12 patients with PMME administered PD-1 inhibitors.

This is a retrospective analysis of the clinical data of 76 patients with PMME who attended Peking University Cancer Hospital between January 2008 and September 2017. Objective response rates (ORRs) and progression-free survival (PFS) were assessed.

The 76 PMMEs were classified as unresectable or metastatic. The patients were allocated to three cohorts according to their treatment: chemotherapy (C: 46 patients), targeted therapy (T: 2 patients), and PD-1 inhibitors (IT: 12 patients). The PFS in the C cohort was three months with a limited ORR of 10.9%. In the IT cohort, seven patients (75.0%) achieved a partial response and three had stable disease for 4+ months. The median PFS in the IT cohort was not reached and the mean was 15.6 months, which was much longer than in cohort C (P

Wang, X., Kong, Y., Chi, Z., Sheng, X., Cui, C., Mao, L., Lian, B., Tang, B., Yan, X., Si, L., and Guo, J. Primary malignant melanoma of the esophagus: A retrospective analysis of clinical features, management, and survival of 76 patients. 21950. 2019 Thorac Cancer.

Concepts Keywords
Chemotherapy Chemotherapy
Cohort Immunotherapy
Esophagus Esophageal cancer
Malignant Melanoma Targeted therapy
Melanoma Progression-free survival
Melanomas Melanoma
Metastatic Adjuvant therapy
Peking Antineoplastic drugs
Targeted Therapy RTT
Cancer treatments
Cancer
Clinical medicine
Medicine
Adjuvant therapy
Chemotherapy
Immunotherapy
Primary malignant melanoma
Rare advanced melanoma

Semantics

Type Source Name
disease DOID melanoma of esophagus
disease DOID Cancer
disease MESH Cancer
gene UNIPROT PDCD1
gene UNIPROT RPL17
pathway BSID Melanoma
disease DOID malignant melanoma
disease MESH malignant melanoma

Original Article

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