Rescuing Suboptimal Outcomes of Subthalamic Deep Brain Stimulation in Parkinson Disease by Surgical Lead Revision.

Rescuing Suboptimal Outcomes of Subthalamic Deep Brain Stimulation in Parkinson Disease by Surgical Lead Revision.

Publication date: Mar 06, 2019

Clinical trials have established subthalamic deep-brain-stimulation (STN-DBS) as a highly effective treatment for motor symptoms of Parkinson disease (PD), but in clinical practice outcomes are variable. Experienced centers are confronted with an increasing number of patients with partially “failed” STN-DBS, in whom motor benefit doesn’t meet expectations. These patients require a complex multidisciplinary and standardized workup to identify the likely cause.

To describe outcomes in a series of PD patients undergoing lead revision for suboptimal motor benefit after STN-DBS surgery and characterize selection criteria for surgical revision.

We investigated 9 PD patients with STN-DBS, who had unsatisfactory outcomes despite intensive neurological management. Surgical revision was considered if the ratio of DBS vs levodopa-induced improvement of UPDRS-III (DBS-rr) was below 75% and the electrodes were found outside the dorsolateral STN.

Fifteen electrodes were replaced via stereotactic revision surgery into the dorsolateral STN without any adverse effects. Median displacement distance was 4.1 mm (range 1.6-8.42 mm). Motor symptoms significantly improved (38.2 +/- 6.6 to 15.5 +/- 7.9 points, P

Nickl, R.C., Reich, M.M., Pozzi, N.G., Fricke, P., Lange, F., Roothans, J., Volkmann, J., and Matthies, C. Rescuing Suboptimal Outcomes of Subthalamic Deep Brain Stimulation in Parkinson Disease by Surgical Lead Revision. 20107. 2019 Neurosurgery.

Concepts Keywords
DBS Neurosurgery
Deep Brain Stimulation Stereotactic surgery
Displacement Subthalamic nucleus
Levodopa Deep brain stimulation
Median Medical devices
Neurological Electrotherapy
Neurosurgery Neurotechnology
Parkinson Neurosurgical procedures
Stereotactic Parkinson’s disease
Medical specialties
Clinical medicine
Medicine
Surgery
Deep brain stimulation
Intensive neurological management

Semantics

Type Source Name
drug DRUGBANK Levodopa
gene UNIPROT LRP2
gene UNIPROT MCF2L
gene UNIPROT EEF1A2
disease DOID Parkinson Disease
disease MESH Parkinson Disease

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