Research details how manganese exposure can contribute to onset of Parkinson’s-like symptoms

Research details how manganese exposure can contribute to onset of Parkinson’s-like symptoms

Publication date: Mar 13, 2019

Anumantha Kanthasamy, a Clarence Hartley Covault Distinguished Professor in veterinary medicine and the Eugene and Linda Lloyd Endowed Chair of Neurotoxicology, said the research details how manganese exposure can lead to misfolded proteins in the brain, which cause a neurological disease. Kanthasamy said small amounts of manganese are necessary for the proper functioning of the human body, but too much exposure has been linked with neurological symptoms much like those experienced by patients with Parkinson’s Disease. Previous studies showed the protein was susceptible to misfolding, but Kanthasamy and his colleagues set out to discover how it interacted with manganese and how that interaction facilitates the progression of disease. The study found welders exposed to manganese had increased misfolded alpha-synuclein serum content, meaning the welders are at a higher risk for developing Parkinson’s symptoms, Kanthasamy said.

Concepts Keywords
Alloy Progression disease
Assay Inflammation
Biomedical Branches of biology
Blood Serum Chemistry
Brain Physical sciences
Inflammation Peripheral membrane proteins
Iowa Neurological disorders
Manganese Lewy body dementia
Misfolding Neuropathology
Neurodegenerative Alpha-synuclein
Neurological Neurodegeneration
Neurological Disorders Manganese
Parkinson Neurotoxin
Protein Alpha
Serum
Vesicles
Veterinary

Semantics

Type Source Name
drug DRUGBANK Manganese
drug DRUGBANK Nonoxynol-9
drug DRUGBANK Tropicamide
disease MESH neurological disorders
gene UNIPROT SET
disease MESH inflammation

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