Statistical Shape Analysis of Subthalamic Nucleus in Patients with Parkinson’s Disease.

Statistical Shape Analysis of Subthalamic Nucleus in Patients with Parkinson’s Disease.

Publication date: Mar 09, 2019

Subthalamic nucleus (STN) is the most targeted localization in the treatment of Parkinson’s disease (PD) with deep brain stimulation (DBS). However, no studies have been found in the literature about possible shape changes of STN in the literature. We aimed to investigate the possible shape changes in the STN and the relationship between shape changes and disease duration in PD patients by using statistical analysis.

Patients who were diagnosed with idiopathic PD and controls were enrolled in this study. Age, sex, and disease duration of the all cases were recorded. Turbo-spin-echo T2-weighted axial series parallel to the skull base in each case containing midbrain images were obtained, including the whole STN. Standard anatomic landmarks were selected and marked on each digital image using a special software in all cases. Statistical geometric shape and deformation analysis of STN performed in two groups.

43 patients with PD and 50 age/sex matched controls were enrolled in this study. There were statistically significant both left and right STN shape differences between the groups. Maximum deformation seen in the dorsolateral parts of the both STN. The general shape variability of the STN were found in left, 0.096 and right, 0.049.

Significant shape differences and remarkable deformation of STN seen in patients with PD compared with controls. Maximum deformation was observed in the dorsolateral part of the STN and with the increase in the duration of the PD, shape differences and deformations become more prominent.

Kaya, M.O., Ozturk, S., , Ercan, Gonen, M., Kocabicak, E., and Erol, F.S. Statistical Shape Analysis of Subthalamic Nucleus in Patients with Parkinson’s Disease. 20100. 2019 World Neurosurg.

Concepts Keywords
DBS Medicine
Deep Brain Stimulation Medical specialties
Deformation Deformation
Digital Image Branches of biology
Geometric Shape Parkinson’s disease
Idiopathic Neuroanatomy
Midbrain STN
Parkinson Subthalamic nucleus
Skull Base Subthalamus
Spin Echo Basal ganglia
Subthalamic Nucleus Deep brain stimulation
T2 Weighted

Semantics

Type Source Name
gene UNIPROT SPIN1
gene UNIPROT GTF2I
gene UNIPROT LRP2
gene UNIPROT MCF2L
gene UNIPROT EEF1A2

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