Melanoma-induced reprogramming of Schwann cell signaling aids tumor growth.

Melanoma-induced reprogramming of Schwann cell signaling aids tumor growth.

Publication date: Mar 26, 2019

The tumor microenvironment has been compared to a non-healing wound involving a complex interaction between multiple cell types. Schwann cells, the key regulators of peripheral nerve repair, have recently been shown to directly affect non-neural wound healing. Their role in cancer progression, however, has been largely limited to neuropathic pain and perineural invasion. In this study, we showed that melanoma activated otherwise dormant functions of Schwann cells aimed at nerve regeneration and wound healing. Such reprogramming of Schwann cells into repair-like cells occurred during the destruction and displacement of neurons as the tumor expanded and via direct signaling from melanoma cells to Schwann cells, resulting in activation of the nerve injury response. Melanoma-activated Schwann cells significantly altered the microenvironment through their modulation of the immune system and the extracellular matrix in a way that promoted melanoma growth in vitro and in vivo. Local inhibition of Schwann cell activity following cutaneous sensory nerve transection in melanoma orthotopic models significantly decreased the rate of tumor growth. Tumor-associated Schwann cells, therefore, can have a significant pro-tumorigenic effect and may present a novel target for cancer therapy.

Shurin, G.V., Kruglov, O., Ding, F., Lin, Y., Hao, X., Keskinov, A.A., You, Z., Lokshin, A.E., LaFramboise, W.A., Falo, L.D., Shurin, and Bunimovich, Y.L. Melanoma-induced reprogramming of Schwann cell signaling aids tumor growth. 22090. 2019 Cancer Res.

Concepts Keywords
Displacement Neuroregeneration
Extracellular Matrix Invasion
Immune System Schwann cell
Melanoma Tumor microenvironment
Microenvironment Nerve injury
Modulation Oncology
Nerve Melanoma
Nerve Injury Neurophysiology
Nerve Regeneration Nervous system
Neurons Organ systems
Neuropathic Pain Branches of biology
Schwann Cells Nerve transection melanoma
Tumor Pain
Tumorigenic
Vivo
Wound Healing

Semantics

Type Source Name
pathway BSID Immune System
disease MESH neuropathic pain
disease DOID cancer
disease MESH multiple
disease MESH growth
disease MESH tumor
disease DOID aids
disease MESH aids
pathway BSID Melanoma
disease DOID Melanoma
disease MESH Melanoma

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