Northwestern researchers find possible link between disrupted sleep-cycles and protection against neurodegenerative diseases

Northwestern researchers find possible link between disrupted sleep-cycles and protection against neurodegenerative diseases

Publication date: Apr 08, 2019

Northwestern researchers experimented on clusters of flies with Huntington’s disease to determine the relationship between altered sleep-wake cycles and neurodegenerative diseases.

Northwestern researchers experimented on clusters of flies with Huntington’s disease to determine the relationship between altered sleep-wake cycles and neurodegenerative diseases.

Northwestern researchers experimented on clusters of flies with Huntington’s disease to determine the relationship between altered sleep-wake cycles and neurodegenerative diseases.

Close When Weinberg Prof. Ravi Allada and his research team began altering the sleeping patterns of a group of fruit flies, they thought a disrupted or unusual sleep-wake cycle would prove to be a risk factor for neurodegenerative diseases.

Allada, whose lab specializes in studying sleep cycles and the effects they have on health, told The Daily the idea for the study came from examining other research that has been conducted on neurodegenerative diseases such as Huntington’s disease.

However, none of the research Allada looked into was able to show if the relationship was causative or correlative, so he said his lab wanted to test the idea that neurodegenerative diseases are caused by poor sleep cycles.

Fangke Xu, an eighth-year Weinberg graduate student and member of Allada’s lab, said the team used fruit flies as models for their study because the flies have similar neurons that govern sleep-wake cycles as humans, and experience similar symptoms from neurodegenerative diseases as humans.

Concepts Keywords
Acne Detrimental neurodegenerative disease
Allada Art acne
Brain Heat shock
Causative Branches of biology
Circadian Clock Circadian rhythm
Circadian Cycles Sleep
Flies CLOCK
Fruit Flies Jet lag
Fruit Fly Brain
Georgia Circadian clock
Heat Shock Period
Jet Lag Cycle
Mutation Flies Huntingtons disease
Neurodegenerative Disease Huntingtons disease
Neurodegenerative Diseases
Neurological Diseases
Neurons
Protein
Refractive Lenses
Risk Factor
Sensor
Sleep
Vital Signs

Semantics

Type Source Name
gene UNIPROT ZNF699
gene UNIPROT WDFY2
disease MESH risk factor
pathway BSID Circadian Clock
gene UNIPROT ANP32B
gene UNIPROT TNFSF13
pathway BSID Release
gene UNIPROT LAT2
gene UNIPROT IMPACT
gene UNIPROT TNFSF14
disease MESH jet lag
gene UNIPROT CLOCK
disease MESH shock
disease DOID neurodegenerative disease
disease MESH acne
disease DOID acne
disease MESH neurodegenerative diseases
pathway BSID Neurodegenerative Diseases

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