Crystal structure of the SH3 domain of human Lyn non-receptor tyrosine kinase.

Crystal structure of the SH3 domain of human Lyn non-receptor tyrosine kinase.

Publication date: Feb 01, 2019

Lyn kinase (Lck/Yes related novel protein tyrosine kinase) belongs to the family of Src-related non-receptor tyrosine kinases. Consistent with physiological roles in cell growth and proliferation, aberrant function of Lyn is associated with various forms of cancer, including leukemia, breast cancer and melanoma. Here, we determine a 1.3 A resolution crystal structure of the polyproline-binding SH3 regulatory domain of human Lyn kinase, which adopts a five-stranded β-barrel fold. Mapping of cancer-associated point mutations onto this structure reveals that these amino acid substitutions are distributed throughout the SH3 domain and may affect Lyn kinase function distinctly.

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Berndt, S., Gurevich, V.V., and Iverson, T.M. Crystal structure of the SH3 domain of human Lyn non-receptor tyrosine kinase. 22261. 2019 PLoS One (14):4.

Concepts Keywords
Amino Acid Lck
Barrel SH3 domain
Breast Receptor tyrosine kinase
Cancer Tyrosine kinase receptors
Crystal Protein domains
Kinase Tyrosine kinases
Lck Oncogenes
Leukemia Branches of biology
Lyn Enzymes
Melanoma
Point Mutations
Receptor Tyrosine Kinase
SH3
SH3 Domain
Src
Tyrosine
Tyrosine Kinase

Semantics

Type Source Name
gene UNIPROT MAP6
drug DRUGBANK Glycine
gene UNIPROT S100B
gene UNIPROT CAPG
gene UNIPROT CD46
gene UNIPROT AOPEP
disease MESH multiple
gene UNIPROT BCAR1
gene UNIPROT TARS
gene UNIPROT SERPINB1
gene UNIPROT EPHA2
gene UNIPROT OXCT2
drug DRUGBANK Proline
gene UNIPROT ZHX1-C8orf768q24.13
drug DRUGBANK Zinc
gene UNIPROT APPL1
gene UNIPROT ACTA1
gene UNIPROT NR4A3
pathway BSID Colorectal cancer
disease DOID colorectal cancer
disease MESH colorectal cancer
gene UNIPROT COL9A3
gene UNIPROT COMP
gene UNIPROT COL9A1
gene UNIPROT COL9A2
gene UNIPROT SCN8A
disease DOID chronic lymphocytic leukemia
gene UNIPROT BRD2
drug DRUGBANK Dasatinib
gene UNIPROT BCR
disease DOID CML
disease DOID CML
gene UNIPROT ADA2
gene UNIPROT PDLIM5
gene UNIPROT FBLIM1
gene UNIPROT PEAK1
disease DOID myeloid leukemia
gene UNIPROT CBARP
disease MESH myeloid leukemia
gene UNIPROT PROC
gene UNIPROT CRK
gene UNIPROT ABL1
gene UNIPROT MTTP
gene UNIPROT DUOXA1
drug DRUGBANK Lauric Acid
drug DRUGBANK Thrombopoietin
gene UNIPROT CPSF4
gene UNIPROT TLR2
pathway BSID Focal adhesion
pathway BSID Focal Adhesion
gene UNIPROT GPR149
drug DRUGBANK Amino acids
gene UNIPROT IK
gene UNIPROT DYRK3
gene UNIPROT THOP1
gene UNIPROT RASA1
gene UNIPROT RGS6
drug DRUGBANK Rasagiline
gene UNIPROT TALDO1
gene UNIPROT LRSAM1
gene UNIPROT DEPP1
gene UNIPROT GOPC
gene UNIPROT HCK
gene UNIPROT LARGE1
disease MESH multi
drug DRUGBANK Trestolone
gene UNIPROT MENT
drug DRUGBANK Serine
gene UNIPROT LBR
gene UNIPROT SYNM
gene UNIPROT FYN
gene UNIPROT CASP8AP2
drug DRUGBANK Nitrogen
drug DRUGBANK Tenoxicam
drug DRUGBANK Imidazole
drug DRUGBANK Glycerin
drug DRUGBANK Tromethamine
disease DOID breast melanoma
disease MESH growth
disease MESH point mutations
pathway BSID Melanoma
disease DOID melanoma
disease MESH melanoma
pathway BSID Breast cancer
disease DOID leukemia
disease DOID breast cancer
disease MESH breast cancer
disease MESH leukemia
disease DOID cancer
disease MESH cancer
gene UNIPROT SRC
gene UNIPROT YES1
gene UNIPROT LCK
drug DRUGBANK L-Tyrosine
gene UNIPROT LYN
gene UNIPROT WASHC1
gene UNIPROT CD40LG
gene UNIPROT SCYL1
gene UNIPROT ACP5
gene UNIPROT TRAF2
gene UNIPROT TDRD7
drug DRUGBANK Lysozyme
gene UNIPROT RORC
drug DRUGBANK Edetic Acid
drug DRUGBANK Isopropyl beta-D-thiogalactopyranoside
gene UNIPROT RAB35
drug DRUGBANK Ampicillin
gene UNIPROT SH3YL1
drug DRUGBANK Bafetinib
drug DRUGBANK Nintedanib
drug DRUGBANK Ponatinib
drug DRUGBANK Bosutinib
disease DOID lung carcinoma
disease MESH renal
gene UNIPROT TNFSF13
gene UNIPROT CEP55
gene UNIPROT ANP32B
gene UNIPROT STAT3

Original Article

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