Deregulated MITF sumoylation: A route to melanoma.

Deregulated MITF sumoylation: A route to melanoma.

Publication date: May 05, 2017

Metastatic melanoma is a deadly form of skin cancer. Extraordinary breakthroughs have been recently achieved in the treatment of the disease, leading to objective increase in patient survival. However, early detection of potential dangerous melanocytic lesions remains the best strategy to avoid metastatic dissemination, which is still the main cause of death in melanoma patients. In 2011, our team identified a germline mutation in microphthalmia-associated transcription factor (MITF ) that predisposes carriers to melanoma. Recently, we demonstrated that this mutation interfered with oncogene-induced senescence, one of the first events that should be overcome to allow melanoma development. Therefore, our works provide important clues on the early steps of melanomagenesis and as such might be useful for prevention or early therapeutic interventions in at risk-patients.

Open Access PDF

Ballotti, R. and Bertolotto, C. Deregulated MITF sumoylation: A route to melanoma. 22271. 2017 Mol Cell Oncol (4):4.

Concepts Keywords
Melanoma RTT
Metastatic Microphthalmia-associated transcription factor
Metastatic Melanoma Cancer
Microphthalmia Branches of biology
MITF Transcription factors
Mutation Melanoma
Oncogene Treatment disease
Senescence
Skin Cancer
Sumoylation
Transcription Factor

Semantics

Type Source Name
pathway BSID Oncogene Induced Senescence
disease MESH metastasis
drug DRUGBANK Rasagiline
gene UNIPROT NIN
gene UNIPROT CTSE
drug DRUGBANK Bismuth subgallate
gene UNIPROT LPO
gene UNIPROT SYNPR
disease MESH familial
gene UNIPROT ZRANB2
disease DOID carcinoma
disease MESH carcinoma
gene UNIPROT DES
drug DRUGBANK Diethylstilbestrol
gene UNIPROT MAGEE1
gene UNIPROT COL9A3
gene UNIPROT COMP
gene UNIPROT COL9A1
gene UNIPROT COL9A2
gene UNIPROT SCN8A
gene UNIPROT EXOG
drug DRUGBANK Pembrolizumab
drug DRUGBANK Ibuprofen
gene UNIPROT CXCL2
gene UNIPROT CARD17
gene UNIPROT DEPP1
gene UNIPROT GOPC
disease MESH repression
gene UNIPROT SIM2
gene UNIPROT PDGFB
disease MESH tumors
gene UNIPROT CDKN2B
gene UNIPROT FRZB
gene UNIPROT CDKN2A
gene UNIPROT SMIM10L2A
gene UNIPROT SMIM10L2B
disease MESH dysplastic nevus
gene UNIPROT MENT
drug DRUGBANK Trestolone
gene UNIPROT SSRP1
disease MESH nevus
gene UNIPROT FATE1
gene UNIPROT SLC35G1
disease DOID kidney cancer
disease MESH kidney cancer
drug DRUGBANK L-Lysine
drug DRUGBANK Glutamic Acid
disease DOID noma
disease MESH noma
gene UNIPROT PTEN
gene UNIPROT TFPI
disease MESH melanocytic nevi
gene UNIPROT BRAF
drug DRUGBANK L-Threonine
drug DRUGBANK Serine
disease MESH point mutation
disease MESH death
gene UNIPROT ARC
gene UNIPROT NOL3
drug DRUGBANK 3 7 11 15-Tetramethyl-Hexadecan-1-Ol
disease MESH ARC
disease MESH development
disease MESH senescence
disease DOID microphthalmia
disease MESH microphthalmia
disease MESH cause of death
gene UNIPROT BEST1
disease DOID skin cancer
disease MESH skin cancer
pathway BSID Melanoma
disease DOID melanoma
disease MESH melanoma
pathway BSID SUMOylation
gene UNIPROT MITF

Similar

Original Article

Leave a Comment

Your email address will not be published. Required fields are marked *