Ultraviolet radiation and cutaneous melanoma: a historical perspective.

Ultraviolet radiation and cutaneous melanoma: a historical perspective.

Publication date: Apr 08, 2019

In this article, we summarize the research that eventually led to the classification of the full ultraviolet (UV) radiation spectrum as carcinogenic to humans. We recall the pioneering works that led to the formulation of novel hypotheses on the reasons underlying the increasing burden of melanoma in light-skinned populations. It took long before having compelling evidence on the association between UV and melanoma, in particular, the importance of UV exposure during childhood for both the occurrence of melanoma and death. The role of UVA was established only after 2005. If molecular lesions caused by UV radiation are better known, the precise mechanism by which UV exposure drives melanoma occurrence and progression still needs to be elucidated. More research on the UV-melanoma relationships has led to more evidence-based sun-protection recommendations, especially for children, and to effective control of the artificial UV tanning fashion. Since around 1985-1995, the mortality because of melanoma has started to decrease in younger age groups in most light-skinned populations. If sun protection among children remain on top of public health agendas, there is a fairly great chance that melanoma mortality will stabilize and steadily decrease in all light-skinned populations. The introduction of effective therapies against metastatic disease will improve this reversal in mortality trends.

Autier, P. and Dor’e, J.F. Ultraviolet radiation and cutaneous melanoma: a historical perspective. 22251. 2019 Melanoma Res.

Concepts Keywords
Carcinogenic Radiation
Melanoma Light skin
Melanoma Mortality Philippe Autier
Metastatic Ultraviolet
Mortality Melanocytic nevus
Radiation Sun tanning
Spectrum Skin pigmentation
Tanning Cancer
Ultraviolet Melanoma
Ultraviolet Radiation Health
UV RTT
UV Radiation Neoplasms
UVA Cutaneous conditions
Radiation
UV melanoma
Mortality melanoma
Burden melanoma

Semantics

Type Source Name
gene UNIPROT RXFP2
drug DRUGBANK Tropicamide
gene UNIPROT THOP1
disease MESH death
gene UNIPROT TNFSF14
pathway BSID Melanoma
disease DOID melanoma
gene UNIPROT SMIM10L2A
disease MESH melanoma
gene UNIPROT SMIM10L2B
disease DOID cutaneous melanoma

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