Body mass index may play a significant role in the progression of multiple sclerosis

Body mass index may play a significant role in the progression of multiple sclerosis

Publication date: Apr 12, 2019

Credit: Casaccia Lab A newly published paper in the Lancet journal EBioMedicine identifies a link between high levels of blood lipids and worsening of disease in multiple sclerosis (MS) patients who are overweight or obese.

“Our study identifies important correlations between ceramide levels, body mass index, and disease progression in MS patients,” said ASRC Neuroscience Initiative Director Patrizia Casaccia, a professor at The Graduate Center.

In this study, however, we also detect higher ceramide levels in the blood of overweight and obese MS patients than we did in patients with normal body mass index, suggesting that overabundant lipids can be derived not only from damaged brain cells, but also from excessive dietary intake of saturated fats. “

For the first group, 54 therapy-nacEFve MS patients 18 to 60 years old with high or normal body mass indexes (BMIs) were evaluated using brain MRI to identify signs of brain damage; a clinical assessment to ascertain weight, disabilities and other vital information; and blood tests to analyze the types of circulating lipids and white blood cells.

Researchers found that MS patients with high BMIs had higher ceramide levels and more circulating monocytes than were evident in healthy individuals with the same BMIs.

Significance The detection of ceramides inside the nucleus of blood cells and the ability of these lipids to induce epigenetic changes suggests that saturated fatty acids may have long-lasting functional effects, which over time steer the MS disease course towards worsening disability.

“We look forward to continuing to work on this important topic through future clinical studies to evaluate the impact of weight management and dietary intervention in MS. ” Castro et al, Body Mass Index in Multiple Sclerosis modulates ceramide-induced DNA methylation and disease course, EBioMedicine (2019).

Concepts Keywords
Blood Human body
Blood Lipids Human weight
BMI Body shape
Body Mass Branches of biology
Body Mass Index MS
Brain Disease
Brain Damage Food
Brain Injury Clinical observations obesity
Casaccia Health
Ceramide Classification of obesity
Ceramides Medical signs
Cerebro Ratios
Counterparts Body mass index
Disability Ceramide
DNA Monocyte
Epigenetic Neuroscience
Epigenomics Epigenomics
Fair Dealing MRI
Fatty Acids
Genetic
Group Therapy
High Blood Lipids
Lancet
Lipids
Methylation
Monocytes
Motor Skills
Mount Sinai
MRI
Multiple Sclerosis
Myelin
Nave
Nerve
Nucleus
Obese
Obesity
Overweight
Prognosis
Saturated Fat
Saturated Fats
Spinal Fluid
White Blood Cells

Semantics

Type Source Name
gene UNIPROT TNFSF13
gene UNIPROT ANP32B
gene UNIPROT IMPACT
disease DOID obesity
drug DRUGBANK Palmitic Acid
disease MESH obesity
gene UNIPROT FAT1
gene UNIPROT CD36
disease MESH lifestyle
drug DRUGBANK Tropicamide
gene UNIPROT TNFSF14
disease MESH habits
gene UNIPROT BAD
pathway BSID Fatty acids
gene UNIPROT CYREN
disease MESH disease progression
disease MESH diagnosis
gene UNIPROT MAGEE1
gene UNIPROT LAT2
drug DRUGBANK Ceramide NP
gene UNIPROT C10orf90
disease MESH overweight
disease DOID multiple sclerosis
disease MESH multiple sclerosis
gene UNIPROT FBN1

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