Damage of the lateral geniculate nucleus in MS: Assessing the missing node of the visual pathway.

Damage of the lateral geniculate nucleus in MS: Assessing the missing node of the visual pathway.

Publication date: Apr 10, 2019

To study if the thalamic lateral geniculate nucleus (LGN) is affected in multiple sclerosis (MS) due to anterograde degeneration from optic neuritis (ON) or retrograde degeneration from optic radiation (OR) pathology, and if this is relevant for visual function.

In this cross-sectional study, LGN volume of 34 patients with relapsing-remitting MS and 33 matched healthy controls (HC) was assessed on MRI using atlas-based automated segmentation (MAGeT). ON history, thickness of the ganglion cell-inner plexiform layer (GC-IPL), OR lesion volume, and fractional anisotropy (FA) of normal-appearing OR (NAOR-FA) were assessed as measures of afferent visual pathway damage. Visual function was tested, including low-contrast letter acuity (LCLA) and Hardy-Rand-Rittler (HRR) plates for color vision.

LGN volume was reduced in patients vs HC (165.5 +/- 45.5 vs 191.4 +/- 47.7 mm, B = -25.89, SE = 5.83, p

LGN volume loss in MS indicates structural damage with potential functional relevance. Our results suggest both anterograde degeneration from the retina and retrograde degeneration from the OR lesions as underlying causes. LGN volume is a promising marker reflecting damage of the visual pathway in MS, with the advantage of individual measurement per patient on conventional MRI.

Papadopoulou, A., Gaetano, L., Pfister, A., Altermatt, A., Tsagkas, C., Morency, F., Brandt, A.U., Hardmeier, M., Chakravarty, M.M., Descoteaux, M., Kappos, L., Sprenger, T., and Magon, S. Damage of the lateral geniculate nucleus in MS: Assessing the missing node of the visual pathway. 17737. 2019 Neurology.

Concepts Keywords
Afferent MRI
Atlas Retina
Brain Optic radiation
Color Vision Blindsight
Cross Radiation
Ganglion Cell Nervous system
IPL Organ systems
Lateral Geniculate Nucleus Lateral geniculate nucleus
Lesion Anatomy
LGN Visual system
MRI Radiation
Multiple Sclerosis
Neurology
Normalized
Optic Neuritis
Pathology
Retina
Retrograde
Thalamic
Visual Pathway

Semantics

Type Source Name
disease MESH visual
disease DOID relapsing-remitting MS
gene UNIPROT CYREN
disease MESH ganglion
gene UNIPROT PHLDA2
disease MESH retrograde degeneration
disease MESH optic neuritis
disease DOID optic neuritis
disease DOID multiple sclerosis
disease MESH multiple sclerosis
gene UNIPROT GPSM2
gene UNIPROT MAGEE1

Original Article

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