Publication date: Apr 10, 2019
‘Nanobodies’ from alpacas could help bring CAR T-cell therapy to solid tumors (Boston Children’s Hospital) Most CAR T-cell therapies look for antigens specific to cancer cells. Using this approach in mouse models, investigators successfully curbed melanoma and colon cancer – solid tumors that currently can’t be treated with CAR T-cell therapy. Complement C5b-9 and Cancer: Mechanisms of Cell Damage, Cancer Counteractions, and Approaches for Intervention In conclusion, osmotic burst of inflated complement-damaged cells may occur, but these bursts are most likely a consequence of metabolic collapse of the cell rather than the cause of cell death. Over the years, ample information on the fine ultrastructure of the MAC that can activate cell death has been gathered (24) and has been recently further examined (. .. Beyond CAR T Cells: Other Cell-Based Immunotherapeutic Strategies Against Cancer Conclusions: CAR T cell therapies have demonstrated the clinical benefits of harnessing our body’s own defenses to combat tumor cells. Most of these modifications use retroviral or lentiviral vectors to integrate the construct, and most of the receptors .. . Inula Viscosa Extract Inhibits Growth of Colorectal Cancer Cells in vitro and in vivo Through Induction of Apoptosis Rinat Bar-Shalom1, Margalit Bergman2, Shlomo Grossman2, Naiel Azzam1, Lital Sharvit1 and Fuad Fares1* 1Department of Human Biology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel 2Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel Colorectal cancer (CRC) is the second most common cancer in females and the third in males worldwide. Inula viscosa (IV) is a well-. .. Bioactivities and Extract Dereplication of Actinomycetales Isolated From Marine Sponges This study aimed to contribute to the need of finding new and more effective bioactive molecules against several of the earlier mentioned threats faced by human kind nowadays. During tumor development, lymphatic endothelial cells (LECs) substantially expand in response to VEGFR-3 engagement by VEGF-C produced in the tumor microenvironment, a process known as tumor-associated lymphangiogenesis. Most derivatives showed cytotoxic activity against colon cancer and melanoma cell lines.