‘Nanobodies’ from alpacas could help bring CAR T-cell therapy to solid tumors

‘Nanobodies’ from alpacas could help bring CAR T-cell therapy to solid tumors

Publication date: Apr 10, 2019

‘Nanobodies’ from alpacas could help bring CAR T-cell therapy to solid tumors (Boston Children’s Hospital) Most CAR T-cell therapies look for antigens specific to cancer cells. Using this approach in mouse models, investigators successfully curbed melanoma and colon cancer – solid tumors that currently can’t be treated with CAR T-cell therapy. Complement C5b-9 and Cancer: Mechanisms of Cell Damage, Cancer Counteractions, and Approaches for Intervention In conclusion, osmotic burst of inflated complement-damaged cells may occur, but these bursts are most likely a consequence of metabolic collapse of the cell rather than the cause of cell death. Over the years, ample information on the fine ultrastructure of the MAC that can activate cell death has been gathered (24) and has been recently further examined (. .. Beyond CAR T Cells: Other Cell-Based Immunotherapeutic Strategies Against Cancer Conclusions: CAR T cell therapies have demonstrated the clinical benefits of harnessing our body’s own defenses to combat tumor cells. Most of these modifications use retroviral or lentiviral vectors to integrate the construct, and most of the receptors .. . Inula Viscosa Extract Inhibits Growth of Colorectal Cancer Cells in vitro and in vivo Through Induction of Apoptosis Rinat Bar-Shalom1, Margalit Bergman2, Shlomo Grossman2, Naiel Azzam1, Lital Sharvit1 and Fuad Fares1* 1Department of Human Biology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel 2Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel Colorectal cancer (CRC) is the second most common cancer in females and the third in males worldwide. Inula viscosa (IV) is a well-. .. Bioactivities and Extract Dereplication of Actinomycetales Isolated From Marine Sponges This study aimed to contribute to the need of finding new and more effective bioactive molecules against several of the earlier mentioned threats faced by human kind nowadays. During tumor development, lymphatic endothelial cells (LECs) substantially expand in response to VEGFR-3 engagement by VEGF-C produced in the tumor microenvironment, a process known as tumor-associated lymphangiogenesis. Most derivatives showed cytotoxic activity against colon cancer and melanoma cell lines.

Concepts Keywords
Actinobacteria Apoptosis
Activation Potential Antibodies
Affinity Cell therapy
Alpacas Drug design
Amide Neurosurgery
Anastasia Colorectal cancer
Antibodies Tumor microenvironment
Antigen Tumor
Antigens Cancer treatments
Antimicrobial Immune system
Apoptosis Health
ATOR RTT
Bacteria Clinical medicine
Bar Ilan University Medicine
Bioactive Drainage
Blood Cell therapy
Boston Predefined tumor
Cancer PNAS targets tumor
Central South University Lymphatic drainage tumor
Changsha Antimicrobial anti cancer
China
Colon
Complement
Continental Shelf
Curbed
Cytotoxic
Cytotoxicity
Drug Design
Drug Resistance
Electron Microscopy
Endothelial
Enhancers
Ethyl
Extracellular
Gene
Geneva
Haifa
Immune Cells
Immunology
Israel
Lentiviral
Linker
Lymph Nodes
Lymphatic System
Lymphoid
Madeira
Manuscript
Marine
MEL
Melanoma
Moiety
Mutation
NCI
Neurosurgery
Osmotic
Parasitic
Pathology
Phylum
PNAS
Portuguese
Propyl
Pyrimidine
Qing
Ramat Gan
Receptors
Retroviral
Ring
SEs
Sponges
Sulphonamide
Switzerland
T Cell
Toxicity
Translocation
Tumor
Tumorigenesis
Ultrastructure
Vectors
VEGF
VEGFR
Vivo

Semantics

Type Source Name
pathway BSID Colorectal cancer
disease DOID Colorectal Cancer
disease MESH Colorectal Cancer
gene UNIPROT DYRK3
gene UNIPROT IK
gene UNIPROT CTLA4
gene UNIPROT TNFRSF4
gene UNIPROT RPL17
gene UNIPROT PDCD1
gene UNIPROT CD274
disease MESH development
gene UNIPROT C5
gene UNIPROT VEGFA
gene UNIPROT FLT4
gene UNIPROT METTL14
gene UNIPROT METTL3
drug DRUGBANK Spinosad
gene UNIPROT HM13
gene UNIPROT GAN
gene UNIPROT NR1H4
gene UNIPROT ADRB2
gene UNIPROT BFAR
gene UNIPROT RAB8A
gene UNIPROT MAGEE1
disease MESH tumorigenesis
gene UNIPROT LARGE1
disease DOID colon cancer
disease MESH colon cancer
pathway BSID Melanoma
disease DOID melanoma
disease MESH melanoma
disease DOID cancer
disease MESH tumors
gene UNIPROT TRIM13
gene UNIPROT CXADR
gene UNIPROT CASR
gene UNIPROT NR1I3
gene UNIPROT PRKAR1A
gene UNIPROT SPG7

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