Opioid Taper Study

Opioid Taper Study

Publication date: Apr 11, 2019

The purpose of this study is to determine the effect of opioid taper on pain sensitivity in patients with chronic pain. In a well-characterized sample of men and women with chronic neuropathic pain on high-dose opioid therapy, experimental pain responses (cold-pressor, quantitative sensory testing) will be serially described over the course of and following an individualized opioid taper. In addition, functional improvements and subject-level predictors of response will be described.

Concepts Keywords
Aim Anxiety disorders
Anxiety Disorders Neurological psychiatric illness
Cardiovascular Pain management
Chronic Pain Pain
Demographic Perception
Empirical Evidence Nociception
Heart Disease Acute pain
High Blood Pressure RTT
Informed Consent Palliative care
IRB Chronic pain
Malignant Opioid
Mental Health Neuropathic pain
Morphine Morphine
Neurological Pain ladder
Neuropathic Opioid rotation
Neuropathic Pain
Nicotine
OIH
Opioid
Opioids
Pacemaker
Pain
Pain Management
Patient Safety
Pennsylvania
Physician
Pressor
Psychiatric Illness
Psychotic
Stroke
Sympathetic Nervous System

Semantics

Type Source Name
disease DOID stroke
disease MESH stroke
disease DOID heart disease
disease MESH heart disease
disease MESH anxiety disorders
drug DRUGBANK Nicotine
disease MESH substance use disorder
gene UNIPROT COL9A3
gene UNIPROT COMP
gene UNIPROT COL9A1
gene UNIPROT COL9A2
gene UNIPROT SCN8A
disease MESH neuropathic pain
gene UNIPROT ELL
disease MESH men
disease MESH chronic pain
disease MESH high blood pressure
gene UNIPROT NR4A2
gene UNIPROT ALG3

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