A Mathematical Representation of Precision Medicine

A Mathematical Representation of Precision Medicine

Publication date: Apr 13, 2019

To fully enable precision medicine, it is necessary to clearly define how each patient’s genome interacts with the unique combination of environmental factors that he or she has been exposed to and understand how these factors interact to cause disease at the individual level.

At the same time, while it is well known that an individual’s lifestyle and environment can impact the development of disease, measurements of environmental contribution are often performed at a population level and are often limited to conventional epidemiological studies with little precision toward a personal level.

They then approached the problem of individual environment and behavior, highlighting recent efforts using electronic health records in deep learning models to predict individual clinical outcomes, attempting to bridge population health and personalized medicine.

Their model, called BADGE for Bayesian Aggregation of Disease Genomic and Environment, provides a novel model to study gene-environment interactions, and is able to hierarchically model genetic risk, environmental factors and their mutual interactions using probabilistic learning techniques.

Concepts Keywords
Bayesian Biosensors
Biosensor Simulation
Biosensors Neural network
Blood Oxygen Level Nature versus nurture
Bridge Medical genetics
Confluence G factor
Deep Learning Personalized medicine
Deep Neural Network Precision medicine
Edge Missing heritability problem
Epidemiological Heritability
Epidemiology Behavioural genetics
Gene Genetics
Genetic Branches of biology
Genome Electronic devices
Glucose Phenotypes P disease
Heart Rate Complex diseases
Heart Rate Variability
Heritability
Interact
Microorganisms
Personalized Medicine
Phenotypes
Precision Medicine
Probabilistic
Respiration
Simulation
Stanford
Temperature

Semantics

Type Source Name
gene UNIPROT LITAF
disease MESH lifestyle
gene UNIPROT IMPACT
disease MESH development
drug DRUGBANK Oxygen
drug DRUGBANK Dextrose unspecified form
drug DRUGBANK D-glucose
gene UNIPROT PTPN5

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