ABC transporters in neurological disorders: an important gateway for botanical compounds mediated neuro-therapeutics.

ABC transporters in neurological disorders: an important gateway for botanical compounds mediated neuro-therapeutics.

Publication date: Apr 12, 2019

Neurodegeneration is a distinguishing feature of many age related disorders. There are a number of factors that can modulate the pathology of these disorders. ATP-binding cassette (ABC) transporters are primarily involved in the maintenance of normal brain homeostasis by eliminating toxic peptides and compounds from the brain. Also, ABC transporters protect the brain from the unwanted effects of endogenous and exogenous toxins that can enter the brain parenchyma. Therefore, these transporters have the ability to determine the pathological outcomes of several neurological disorders. For instance, ABC transporters like P-glycoprotein (ABCB1), and BCRP (ABCG2) have been reported to facilitate the clearance of peptides such as amyloid-β (Aβ) that accumulate in the brain during Alzheimer’s disease (AD) progression. Other members such as ABCA1, ABCA2, ABCC8, ABCC9, ABCG1 and ABCG4 also have been reported to be involved in the progression of various brain metabolic disorders such as HIV-associated dementia, Multiple sclerosis (MS), Ischemic stroke, and Epilepsy. However, these defective transporters can be targeted by numerous botanical compounds such as Verapamil, Berberine and Fascalpsynas a therapeutic target to treat these neurological outcomes. These compounds are already reported to modulate ABC transporter activity in the CNS. Nonetheless, the exact mechanisms involving the ABC transporters role in normal brain functioning, their role in neuronal dysfunction and how these botanical compounds ensure and facilitate their therapeutic action in association with defective transporters still remain elusive. This review therefore, summarizes the role of ABC transporters in neurological disorders, with a special emphasis on its role in AD brains. The prospect of using botanical/natural compounds as modulators of ABC transporters in neurological disorders is discussed in the latter half of the article.

Jha, N.K., Kar, R., and Niranjan, R. ABC transporters in neurological disorders: an important gateway for botanical compounds mediated neuro-therapeutics. 17743. 2019 Curr Top Med Chem.

Concepts Keywords
ABC Transporter ABCG1
ABC Transporters ABCA1
ABCB1 ABCG2
Alzheimer P-glycoprotein
Amyloid ABCA2
ATP Binding Cassette ABCC8
Berberine ATP-binding cassette transporter
Brain Branches of biology
Dementia ABC transporters
Endogenous Related disorders
Epilepsy HIV
Exogenous Neurological disorders
Glycoprotein Dysfunction
HIV
Homeostasis
Ischemic Stroke
Metabolic Disorders
Multiple Sclerosis
Neurodegeneration
Neurological
Neurological Disorders
Parenchyma
Pathology
Peptides
Verapamil

Semantics

Type Source Name
drug DRUGBANK Berberine
drug DRUGBANK Verapamil
disease DOID Epilepsy
disease MESH Epilepsy
disease DOID Multiple sclerosis
disease MESH Multiple sclerosis
disease DOID dementia
disease MESH dementia
gene UNIPROT ABCG4
gene UNIPROT ABCG1
gene UNIPROT ABCC9
gene UNIPROT ABCC8
gene UNIPROT ABCA2
gene UNIPROT ABCA1
gene UNIPROT ABCG2
gene UNIPROT ABCB1
gene UNIPROT ABCB6
drug DRUGBANK Abacavir
gene UNIPROT ATP8A2
drug DRUGBANK ATP
disease MESH neurological disorders
pathway BSID ABC transporters

Original Article

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