Antioxidant and Anti-melanogenic activities of Compounds isolated from the Aerial parts of Achillea alpina L.

Antioxidant and Anti-melanogenic activities of Compounds isolated from the Aerial parts of Achillea alpina L.

Publication date: Apr 11, 2019

Achillea alpina is widely distributed in Korea and is often used as a folk medicine for stomach disorders. Although a previous study isolated antioxidant compounds (flavonoid O-glucoside, sesquiterpene) from this plant, no systematic study of its chemical constituents had been reported. The present study aimed to identify the phytochemicals present in a methanol extract of A. alpina, assess their potential antioxidant activities in vitro, and determine their effects on melanogenesis in B16F10 melanoma cells. Column chromatographic separation of aqueous fractions of A. alpina led to the isolation of 17 compounds. The chemical structures of these compounds were determined using spectroscopic data from electrospray ionization-mass spectrometry and nuclear magnetic resonance. To the best of our knowledge, the present study is the first to identify compounds 2 10 and 12 17 in A. alpina. Furthermore, compound 6 possessed powerful antioxidant activity, while compound 15 suppressed intracellular tyrosinase activity and thus reduced melanogenesis in B16F10 cells. Therefore, our research suggested that these naturally occurring compounds have the potential to reduce oxidative stress and to promote skin whitening. Further investigations will be required to elucidate the mechanisms underlying the antioxidant and anti-tyrosinase activities of these compounds.

Cho, H.W., Lee, H.J., Sim, M.O., Woo, K.W., Jeong, D.E., Jung, H.K., and An, B. Antioxidant and Anti-melanogenic activities of Compounds isolated from the Aerial parts of Achillea alpina L. 22288. 2019 Chem Biodivers.

Concepts Keywords
Achillea Flavonoid
Alpina Tyrosinase
Antioxidant Antioxidant
Chromatographic Physiology
Electrospray Ionization Skin whitening
Flavonoid Light skin
Folk Colorism
Glucoside Nutrients
Intracellular Nutrition
Korea Articles
Mass Spectrometry Branches of biology
Melanogenesis Melanogenesis B16F10 melanoma
Melanoma
Methanol
Nuclear Magnetic Resonance
Oxidative Stress
Phytochemicals
Sesquiterpene
Skin Whitening
Spectroscopic
Stomach
Tyrosinase

Semantics

Type Source Name
pathway BSID Oxidative Stress
disease MESH oxidative stress
drug DRUGBANK N-(Allyloxycarbonyl)-4-[N-(Carboxy-Formyl)-2-(Benzoic Acid)-Amino]-L-Phenylalani
gene UNIPROT BEST1
gene UNIPROT FBN1
gene UNIPROT SMIM10L2A
gene UNIPROT SMIM10L2B
disease MESH separation
pathway BSID Melanoma
disease DOID melanoma
disease MESH melanoma
pathway BSID Melanogenesis
drug DRUGBANK Beta-D-Glucose

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