Clinical, neuropathological and genetic features of Lewy body dementias.

Clinical, neuropathological and genetic features of Lewy body dementias.

Publication date: Apr 12, 2019

Lewy body dementias are the second most common neurodegenerative dementias after Alzheimer’s disease, and include dementia with Lewy bodies and Parkinson’s disease dementia. They share similar clinical and neuropathological features but differ in the time of dementia and parkinsonism onset. Although Lewy bodies are their main pathological hallmark, several studies have shown the emerging importance of Alzheimer’s disease pathology. Clinical amyloid-β imaging using Pittsburgh Compound B (PiB) supports neuropathological studies which found that amyloid-β pathology is more common in dementia with Lewy bodies than in Parkinson’s disease dementia. Nevertheless, other co-occurring pathologies, such as cerebral amyloid angiopathy, TDP-43 pathology and synaptic pathology may also influence the development of neurodegeneration and dementia. Recent genetic studies demonstrated an important role of APOE genotype, and other genes such as GBA and SNCA which seem to be involved in the pathophysiology of Lewy body dementias. The aim of this article is to review the main clinical, neuropathological and genetic aspects of dementia with Lewy bodies and Parkinson’s disease dementia. This is particularly relevant as future management for these two conditions may differ. This article is protected by copyright. All rights reserved.

Hansen, D., Ling, H., Lashley, T., Holton, J.L., and Warner, T.T. Clinical, neuropathological and genetic features of Lewy body dementias. 20446. 2019 Neuropathol Appl Neurobiol.

Concepts Keywords
Alzheimer Genotype
Amyloid Alzheimer’s disease
APOE Learning disabilities
Cerebral Amyloid Angiopathy RTT
Dementia Medicine
Genetic Cognitive disorders
Genotype Psychiatry
Lewy Bodies Psychiatric diagnosis
Neurodegeneration Lewy body dementia
Neurodegenerative Branches of biology
Neuropathological Disease
Parkinson Dementias
Parkinsonism Dementia parkinsonism
Pathologies Dementia
Pathology Amyloid imaging
Pathophysiology
Pittsburgh
SNCA
Synaptic
TDP

Semantics

Type Source Name
gene UNIPROT DNMT1
gene UNIPROT CD69
gene UNIPROT CD5L
gene UNIPROT SNCA
gene UNIPROT GBA
gene UNIPROT APOE
disease MESH development
gene UNIPROT TARDBP
disease DOID cerebral amyloid angiopathy
disease MESH cerebral amyloid angiopathy
disease DOID dementia
disease DOID dementia with Lewy bodies
disease MESH dementias

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