Excess Body Fat Spurs Disease Progression by Impact on Immune Cells, Study Suggests

Excess Body Fat Spurs Disease Progression by Impact on Immune Cells, Study Suggests

Publication date: Apr 12, 2019

A link between fat molecules called ceramides and worsening disease in overweight and obese people with multiple sclerosis (MS) appears to exist, a study reports, with its findings suggesting that ceramides prompt the growth of immune cells called monocytes , which in turn spurs disease progression. To test this hypothesis, a team led by researchers at the Advanced Science Research Center (ASRC) at The Graduate Center and at the Icahn School of Medicine at Mount Sinai analyzed 54 patients with relapsing-remitting MS (MS), ages 18 to 60, and with normal or high BMIs (27 people in each group). The researchers also found more methylation on the genomes of monocytes from high-BMI patients than those from low-BMI patients, and they noted that the overweight or obese patients also tended to have greater disease activity, worse disability progression, and more brain lesions on MRI (magnetic resonance imaging) scans on follow-up. Mice fed the high-fat diet were found to have greater disease severity, more brain lesions, and more monocytes, confirming the findings seen in MS patients. -Our findings suggest that increased levels of saturated fat as a result of dietary habits are one likely cause of the epigenetic changes that advance MS, which gives us a starting point for a potential intervention. ” -It will also be important to evaluate the effectiveness of dietary intervention (with an emphasis on the reduction of specific classes of saturated fats), as potential modulator of plasma ceramide levels and possibly of disease course in MS patients. “

Concepts Keywords
Bacteria Multiple Sclerosis
Biomarkers MS
Blood Food
BMI Differences groups
Body Fat Weight management
Body Mass Branches of biology
Body Mass Index Human weight
Brain Body shape
Brain Damage Cell biology
Cellular Signaling Immune system
Ceramide Medical signs
Ceramides Body mass index
Cross Overweight
Disability Obesity
Epigenetic Monocyte
Epigenomics Macrophage
Fat Ceramide
Genetic Epigenomics
Lipid MRI
Lipids Magnetic resonance imaging
Macrophages
Magnetic Resonance Imaging
Methylation
Monocytes
Mount Sinai
MRI
Multiple Sclerosis
Nerve
Obese
Overweight
Plasma
Prognosis
Saturated Fat
Saturated Fats

Semantics

Type Source Name
drug DRUGBANK Palmitic Acid
gene UNIPROT FAT1
gene UNIPROT CD36
disease MESH Disease Progression
gene UNIPROT IMPACT
disease MESH overweight
disease MESH multiple sclerosis
disease DOID multiple sclerosis
drug DRUGBANK Ceramide NP
disease MESH growth
gene UNIPROT FBN1
gene UNIPROT SMIM10L2B
gene UNIPROT SMIM10L2A
disease DOID relapsing-remitting MS
gene UNIPROT BEST1
gene UNIPROT MAGEE1
gene UNIPROT SET
pathway BSID Methylation
gene UNIPROT CYREN
pathway BSID Release
disease MESH habits
gene UNIPROT C10orf90

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