Gait impairments in Parkinson’s disease.

Gait impairments in Parkinson’s disease.

Publication date: Apr 08, 2019

Gait impairments are among the most common and disabling symptoms of Parkinson’s disease. Nonetheless, gait is not routinely assessed quantitatively but is described in general terms that are not sensitive to changes ensuing with disease progression. Quantifying multiple gait features (eg, speed, variability, and asymmetry) under natural and more challenging conditions (eg, dual-tasking, turning, and daily living) enhanced sensitivity of gait quantification. Studies of neural connectivity and structural network topology have provided information on the mechanisms of gait impairment. Advances in the understanding of the multifactorial origins of gait changes in patients with Parkinson’s disease promoted the development of new intervention strategies, such as neurostimulation and virtual reality, aimed at alleviating gait impairments and enhancing functional mobility. For clinical applicability, it is important to establish clear links between specific gait impairments, their underlying mechanisms, and disease progression to foster the acceptance and usability of quantitative gait measures as outcomes in future disease-modifying clinical trials.

Mirelman, A., Bonato, P., Camicioli, R., Ellis, T.D., Giladi, N., Hamilton, J.L., Hass, C.J., Hausdorff, J.M., Pelosin, E., and Almeida, Q.J. Gait impairments in Parkinson’s disease. 20449. 2019 Lancet Neurol.

Concepts Keywords
Clinical Trials Virtual reality
Gait Branches of biology
Lancet Applied sciences
Network Topology Academic disciplines
Neurostimulation Gait
Parkinson Parkinson’s disease
Usability Posture
Virtual Reality Walking
Terrestrial locomotion
Dance science


Type Source Name
disease MESH development
disease MESH multiple
disease MESH disease progression
disease MESH Gait


Original Article

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