Neurofilament light chain levels in pregnant multiple sclerosis patients: a prospective cohort study.

Neurofilament light chain levels in pregnant multiple sclerosis patients: a prospective cohort study.

Publication date: Apr 12, 2019

Neurofilament light chain (NfL) is a cytoskeletal protein of neurons. Its levels are increasingly recognized as measures of neuroaxonal damage. The aim of this study was to explore serum NfL (sNfL) levels in MS patients and healthy controls during pregnancy and puerperium.

Prospective, longitudinal, single-center study. sNfL concentration was assessed using a highly sensitive single-molecule array during pregnancy and in puerperium, in a cohort of 39 pregnant patients with relapsing multiple sclerosis (P-MS). Twenty-one healthy pregnant women (HPW) served as control groups. Eight R-MS patients suffered relapses during pregnancy (P-MS-R) in the first or second trimesters.

No differences in pregnancy and delivery data were observed between P-MS and HPW. P-MS patients showed higher sNfL values than HPW in the first trimester, independently of the presence (p=0.002) or not (p=0.02) of relapses during pregnancy. However, in the third trimester, only P-MS-R showed higher sNfL values than HPW (p=0.001). These differences extended to the puerperium, where P-MS-R showed higher sNfL values than those with no relapses during gestation (p=0.02).

These data strongly suggest that sNfL levels reflect MS activity during pregnancy. Additionally, the absence of relapses during pregnancy may have a beneficial effect on neurodegeneration during puerperium. This article is protected by copyright. All rights reserved.

Cuello, J.P., Mart’inez Gin’es, M.L., Kuhle, J., Garc’ia Dom’inguez, J.M., Lozano Ros, A., Romero Delgado, F., Higueras, Y., Melda~na Rivera, A., Goicochea Brice~no, H., Garc’ia-Tizon Larroca, S., de-Le’on Ruiz, J., Michalak, Z., Barro, C., ‘Alvarez Lafuente, R., Medina Heras, S., Fern’andez Velasco, J.I., Tejeda-Velarde, A., Dom’inguez-Mozo, M.I., Muriel, A., de Andr’es, C., and Villar, L.M. Neurofilament light chain levels in pregnant multiple sclerosis patients: a prospective cohort study. 17742. 2019 Eur J Neurol.

Concepts Keywords
Cohort Postpartum period
Cytoskeletal Multiple sclerosis
Gestation RTT
Molecule Pregnancy
Multiple Sclerosis Fertility
Neurodegeneration Family
Neurofilament Motherhood
Neurons Birth control
NfL Human reproduction
Pregnancy Women’s health
Prospective Cohort Study MS
Puerperium Pregnant multiple sclerosis
Serum

Semantics

Type Source Name
disease MESH relapses
gene UNIPROT DNMT1
gene UNIPROT CD69
gene UNIPROT CD5L
gene UNIPROT MAGEE1
gene UNIPROT NEFL
disease DOID multiple sclerosis
disease MESH multiple sclerosis
gene UNIPROT TNFSF14

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