Nicotine improved the olfactory impairment in MPTP-Induced Mouse Model of Parkinson’s Disease.

Nicotine improved the olfactory impairment in MPTP-Induced Mouse Model of Parkinson’s Disease.

Publication date: Apr 09, 2019

Olfactory impairment is an early feature of patients with Parkinson’s disease (PD). Retrospective epidemiological studies reported lower scores on the University of Pennsylvania Smell Identification Test (UPSIT) in non-smokers than smokers with PD and showed an inverse correlation between susceptibility to PD and a person’s history of smoking. But the mechanisms by which cigarettes affect olfaction in PD are not fully understood. So we investigated the effect of nicotine on the olfactory function in 1-methyl-4-phenyl-1, 2, 3, 6 tetrahydropyridine (MPTP)-treated mice. We observed that nicotine improved locomotor activity and protection against dopaminergic neuron loss in the midbrain in MPTP-treated mice. Compared to controls, MPTP-treated mice showed a deficit of odor discrimination and odor detection, which were alleviated by nicotine treatment. But no significant changes were found in olfactory memory in MPTP-treated mice. Moreover, we detected a marked decrease of Choline acetyltransferase (ChAT) expression in the olfactory bulb (OB) in MPTP-treated mice, which was also attenuated by nicotine administration. In addition, nicotine ameliorated the loss of cholinergic neurons and dopaminergic innervation in the horizontal limb of the diagonal band (HDB), which is the primary origin of cholinergic input to the OB. Our results suggested that nicotine could improve the olfactory impairment by protecting cholinergic systems in the OB of MPTP-treated mice. And nicotine protection of cholinergic systems in the OB is relevant to attenuating dopaminergic neuron loss in the midbrain and HDB.

Yang, J., Lv, D.J., Li, L.X., Wang, Y.L., Qi, D., Chen, J., Mao, C.J., Wang, F., Liu, Y., Hu, L.F., and Liu, C.F. Nicotine improved the olfactory impairment in MPTP-Induced Mouse Model of Parkinson’s Disease. 20444. 2019 Neurotoxicology.

Concepts Keywords
Cholinergic Nicotine
Correlation Cholinergic neuron
Discrimination Olfaction
Dopaminergic Pyridines
Epidemiological Prodrugs
HDB Neurotoxins
Locomotor Activity MPTP
Memory Brain
Methyl Limbic system
Mice Branches of biology
Midbrain Chemical compounds
MPTP
Neurons
Nicotine
Olfaction
Olfactory
Olfactory Bulb
Parkinson
Pennsylvania
Phenyl
Smoking
Test

Semantics

Type Source Name
gene UNIPROT INTS6
gene UNIPROT SH2D3C
gene UNIPROT CHAT
drug DRUGBANK Choline
disease MESH smokers
drug DRUGBANK Nicotine

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