TMEM10 in Demyelinated MS Lesions May Contribute to Remyelination, Study Suggests

TMEM10 in Demyelinated MS Lesions May Contribute to Remyelination, Study Suggests

Publication date: Apr 12, 2019

A protein that promotes nervous system repair through remyelination – the creation of myelin, the protective sheath around nerve cells – in mice also is found in remyelinating plaques in brains of multiple sclerosis (MS) patients, new research shows. This protein potentially represents a new therapeutic target in demyelinating disorders like MS. The research article reporting the findings is titled – TMEM10 Promotes Oligodendrocyte Differentiation and is Expressed by Oligodendrocytes in Human Remyelinating Multiple Sclerosis Plaques, ” and was published in the journal Nature Scientific Reports. Remyelination occurs through oligodendrocyte differentiation – when oligodendrocyte precursor cells (OPCs) grow to form oligodendrocytes that can create new myelin sheaths on demyelinated nerve projections. For these reasons, researchers from McGill University, in Canada, studied the role of TMEM10 in mouse nervous system development, oligodendrocyte differentiation, and myelination. Overall, the findings -provide evidence that TMEM10 promotes oligodendrocyte precursor cell differentiation, and suggest that TMEM10 expressed in demyelinated MS lesions may contribute to remyelination,” the researchers wrote.

Concepts Keywords
Brain Nervous systems
Canada MS
Central Nervous System Glial cells
Lesion Branches of biology
McGill University Nervous system
Multiple Sclerosis Organ systems
Myelin Neurology
Myelination Remyelination
Nerve Oligodendrocyte progenitor cell
Nervous System Multiple sclerosis
Oligodendrocyte Polydendrocytes
Scientific Reports


Type Source Name
disease MESH multiple sclerosis
disease DOID multiple sclerosis
disease MESH demyelinating disorders
disease MESH development


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