Publication date: Apr 12, 2019
A protein that promotes nervous system repair through remyelination – the creation of myelin, the protective sheath around nerve cells – in mice also is found in remyelinating plaques in brains of multiple sclerosis (MS) patients, new research shows. This protein potentially represents a new therapeutic target in demyelinating disorders like MS. The research article reporting the findings is titled – TMEM10 Promotes Oligodendrocyte Differentiation and is Expressed by Oligodendrocytes in Human Remyelinating Multiple Sclerosis Plaques, ” and was published in the journal Nature Scientific Reports. Remyelination occurs through oligodendrocyte differentiation – when oligodendrocyte precursor cells (OPCs) grow to form oligodendrocytes that can create new myelin sheaths on demyelinated nerve projections. For these reasons, researchers from McGill University, in Canada, studied the role of TMEM10 in mouse nervous system development, oligodendrocyte differentiation, and myelination. Overall, the findings -provide evidence that TMEM10 promotes oligodendrocyte precursor cell differentiation, and suggest that TMEM10 expressed in demyelinated MS lesions may contribute to remyelination,” the researchers wrote.
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