Metastatic malignant melanoma to the esophagus, first case diagnosed by endoscopic ultrasound (EUS) guided fine needle aspiration (FNA).

Metastatic malignant melanoma to the esophagus, first case diagnosed by endoscopic ultrasound (EUS) guided fine needle aspiration (FNA).

Publication date: Apr 13, 2019

Metastatic malignant melanoma to the esophagus is extremely rare. An extensive literature search revealed only 17 reports since 1895. All were diagnosed on surgical specimens. We report a case of metastatic malignant melanoma to the esophagus; the first documented case diagnosed by EUS-guided FNA. A 91-year-old man developed a cough for 8 months. Past medical history included asbestos exposure and resection of melanoma of left neck 21 years ago. He underwent CT chest, which revealed a 4×5 cm mid mediastinal mass, apparently contiguous with the esophagus. Subsequent EUS examination showed an intramural lesion likely originating from the submucosa of the esophageal wall. Cytology examination revealed many large epithelioid malignant tumor cells with high grade bizarre nuclei, prominent macronucleoli and occasional intranuclear inclusions. Immunohistochemistry showed positive staining for S-100, SOX-10, Melanin A, while negative staining for AE1/AE3, CK7, CK20, TTF-1, P63, calretinin and C-kit. Combined morphology and immunoprofile were consistent with metastatic malignant melanoma. This article is protected by copyright. All rights reserved.

Ahsan, B.U., Alhamar, M., Pompa, R., Schultz, D., and Zhang, Z. Metastatic malignant melanoma to the esophagus, first case diagnosed by endoscopic ultrasound (EUS) guided fine needle aspiration (FNA). 22298. 2019 Cytopathology.

Concepts Keywords
Asbestos Ultrasound
Cough Clinical medicine
Cytology Mediastinal tumor
Cytopathology Esophageal cancer
Endoscopic Ultrasound Calretinin
Epithelioid Endoscopic ultrasound
Esophagus Cancer
EUS Medicine
Fine Needle Aspiration Neoplasms
FNA Melanoma
Immunohistochemistry RTT
Lesion Tumor
Malignant Melanoma Rare extensive search
Malignant Tumor
Melanin
Melanoma
Metastatic
Morphology
Nuclei
Resection
SOX
Staining
Submucosa

Semantics

Type Source Name
gene UNIPROT KIT
gene UNIPROT UVRAG
gene UNIPROT RPE65
gene UNIPROT TP63
gene UNIPROT CKAP4
gene UNIPROT TTF1
gene UNIPROT NKX2-1
gene UNIPROT LIAT1
gene UNIPROT KRT20
gene UNIPROT KRT7
gene UNIPROT SLC4A3
gene UNIPROT SLC4A1
disease DOID malignant tumor
gene UNIPROT LARGE1
gene UNIPROT FBN1
gene UNIPROT FBXW7
pathway BSID Melanoma
gene UNIPROT EHD1
disease DOID malignant melanoma
disease MESH malignant melanoma

Original Article

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