The Role of Autophagy in Liver Epithelial Cells and Its Impact on Systemic Homeostasis.

The Role of Autophagy in Liver Epithelial Cells and Its Impact on Systemic Homeostasis.

Publication date: Apr 11, 2019

: Autophagy plays a role in several physiological and pathological processes as it controls the turnover rate of cellular components and influences cellular homeostasis. The liver plays a central role in controlling organisms’ metabolism, regulating glucose storage, plasma proteins and bile synthesis and the removal of toxic substances. Liver functions are particularly sensitive to autophagy modulation. In this review we summarize studies investigating how autophagy influences the hepatic metabolism, focusing on fat accumulation and lipids turnover. We also describe how autophagy affects bile production and the scavenger function within the complex homeostasis of the liver. We underline the role of hepatic autophagy in counteracting the metabolic syndrome and the associated cardiovascular risk. Finally, we highlight recent reports demonstrating how the autophagy occurring within the liver may affect skeletal muscle homeostasis as well as different extrahepatic solid tumors, such as melanoma.

Tomaipitinca, L., Mandatori, S., Mancinelli, R., Giulitti, F., Petrungaro, S., , Moresi, Facchiano, A., Ziparo, E., Gaudio, E., and Giampietri, C. The Role of Autophagy in Liver Epithelial Cells and Its Impact on Systemic Homeostasis. 22302. 2019 Nutrients (11):4.

Concepts Keywords
Autophagy Programmed cell death
Bile MTOR
Cardiovascular Liver
Fat Immunology
Glucose Autophagy
Hepatic Branches of biology
Homeostasis
Lipids
Liver
Melanoma
Metabolic Syndrome
Metabolism
Modulation
Plasma
Scavenger
Skeletal Muscle

Semantics

Type Source Name
pathway BSID Oxidative Stress
disease MESH oxidative stress
disease DOID cancer
pathway BSID Melanoma
disease DOID melanoma
disease MESH melanoma
disease MESH tumors
disease MESH metabolic syndrome
gene UNIPROT CD36
gene UNIPROT FAT1
drug DRUGBANK Palmitic Acid
disease MESH bile
drug DRUGBANK D-glucose
drug DRUGBANK Dextrose unspecified form
pathway BSID Metabolism
disease MESH pathological processes
gene UNIPROT IMPACT

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