Patterns of Care and Survival Outcomes in the Treatment of Anal Melanoma.

Patterns of Care and Survival Outcomes in the Treatment of Anal Melanoma.

Publication date: Apr 15, 2019

Anal mucosal melanoma is an uncommon malignancy of the anal canal, with few large studies available to establish clear trends in the treatment modalities presently available. The primary goal of this study was to identify the patterns of care in the treatment of anal melanoma and secondarily to determine outcomes.

This was a retrospective study performed utilizing the National Cancer Database (NCDB). A total of 787 patients diagnosed with anal melanoma between 2004 and 2014 were selected, of which 398 had staging information. The four treatment groups analyzed were surgical excision alone, surgical excision and radiation therapy, surgical excision and immunotherapy/chemotherapy, and radiation therapy plus minus immunotherapy/chemotherapy. Treatment was grouped by extent of disease; the Kaplan-Meier method was used to analyze overall survival and multivariate Cox proportional model was used to identify factors associated with overall survival.

The majority of patients presented with either node-positive (39.4%) or metastatic disease (37.4%). Patients with surgical excision and radiation therapy had the highest median survival at 32.3 months. This is in contrast with those receiving surgical excision alone (22.9 months), surgery and immunotherapy/chemotherapy (18.4 months), and radiation without surgery (5.1 months) (p 

Naqvi, J., Lee, A., Lederman, A., Kavi, A., Osborn, V.W., and Schreiber, D. Patterns of Care and Survival Outcomes in the Treatment of Anal Melanoma. 22317. 2019 J Gastrointest Cancer.

Concepts Keywords
Anal Canal Chemotherapy
Chemotherapy Radiation
Immunotherapy Anal cancer
Malignancy Basal-cell carcinoma
Melanoma Radiation therapy
Metastatic Cancer
Multivariate Health
Radiation Medicine
Radiation Therapy Neoplasms
Melanoma
RTT
Chemotherapy
Immunotherapy
Surgery
Radiation therapy
Anal melanoma
Extent disease

Semantics

Type Source Name
disease DOID Dermatitis
disease MESH Dermatitis
disease DOID Rash
gene UNIPROT SDC1
gene UNIPROT MECP2
disease DOID carcinoma
disease MESH carcinoma
disease DOID Anal cancer
disease MESH Anal cancer
pathway BSID Melanoma
disease DOID Melanoma
disease MESH Melanoma
gene UNIPROT COX5A
gene UNIPROT COX8A
gene UNIPROT CPOX
disease DOID Cancer
gene UNIPROT LARGE1
disease MESH malignancy
disease DOID mucosal melanoma
disease DOID Anal Melanoma

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