The Healthcare Systems Research Network (HCSRN) as an Environment for Dissemination and Implementation Research: A Case Study of Developing a Multi-Site Research Study in Precision Medicine.

The Healthcare Systems Research Network (HCSRN) as an Environment for Dissemination and Implementation Research: A Case Study of Developing a Multi-Site Research Study in Precision Medicine.

Publication date: Apr 12, 2019

In existence for nearly 25 years, the Healthcare Systems Research Network (HCSRN) is an established and sustainable network of health care systems that serves as a “real world” laboratory to enable the integration of research findings into practice. The objective of this paper is to demonstrate how the HCSRN serves as an ideal environment for studying dissemination and implementation of evidence-based practices into health care systems through the example of developing a multi-site study on the implementation of evidence-based precision medicine practices.

The “Implementing Universal Lynch Syndrome Screening (IMPULSS)” study (NIH R01CA211723) involves seven HCSRN health care systems and two external health care systems. The IMPULSS study will describe and explain organizational variability around Lynch syndrome (LS) screening to identify which factors in different organizational contexts are important for successful implementation of LS screening programs and will create a toolkit to facilitate organizational decision making around implementation and improvement of precision medicine programs in health care systems.

The strengths of the HCSRN that facilitate D&I research include: 1) a culture of collaboration, 2) standardization of data and processes across systems, and 3) researchers embedded in diverse health care systems. We describe how these strengths contributed to developing the IMPULSS study.

Given the importance of conducting research in real world settings to improve patient outcomes, the unique strengths of the HCSRN are of vital importance. The IMPULSS study is one case example of how the strengths of the HCSRN make it an excellent environment for research on implementing evidence-based precision medicine practices in health care systems.

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Rahm, A.K., , Ladd, Burnett-Hartman, A.N., Epstein, M.M., Lowery, J.T., Lu, C.Y., Pawloski, P.A., Sharaf, R.N., Liang, S.Y., and Hunter, J.E. The Healthcare Systems Research Network (HCSRN) as an Environment for Dissemination and Implementation Research: A Case Study of Developing a Multi-Site Research Study in Precision Medicine. 04421. 2019 EGEMS (Wash DC) (7):1.

Concepts Keywords
Lynch Syndrome Precision medicine
NIH Health policy
Precision Medicine Health system
Health care
Healthcare quality
Evidence-based medicine
Articles
Health
Multi site

Semantics

Type Source Name
pathway BSID Reproduction
gene UNIPROT TNFSF13
gene UNIPROT ANP32B
drug DRUGBANK Nordazepam
gene UNIPROT KIT
gene UNIPROT HRAS
gene UNIPROT KRAS
disease DOID Substance abuse
disease MESH Substance abuse
gene UNIPROT CEP55
gene UNIPROT SHCBP1
gene UNIPROT PAM
gene UNIPROT LRIT1
gene UNIPROT PFDN1
gene UNIPROT PDF
gene UNIPROT GDF15
gene UNIPROT DOCK11
disease MESH familial
gene UNIPROT COL9A3
gene UNIPROT COMP
gene UNIPROT COL9A1
gene UNIPROT COL9A2
gene UNIPROT SCN8A
gene UNIPROT CTNNA2
disease DOID Cancer
gene UNIPROT FANCE
gene UNIPROT ELOVL6
disease DOID face
gene UNIPROT CTNNBL1
gene UNIPROT CREM
gene UNIPROT FAM20C
gene UNIPROT SSRP1
gene UNIPROT MENT
drug DRUGBANK Trestolone
disease DOID colon cancer
disease MESH colon cancer
gene UNIPROT CDIPT
disease MESH diagnoses
gene UNIPROT PAGE5
pathway BSID Endometrial cancer
disease DOID Endometrial Cancer
pathway BSID Colorectal cancer
disease DOID Colorectal Cancer
disease MESH Colorectal Cancer
disease DOID ers
gene UNIPROT PDLIM5
gene UNIPROT EHD1
gene UNIPROT PAGE4
disease MESH mismatch repair deficiency
disease MESH tumors
disease MESH endometrial cancers
pathway BSID Mismatch Repair
pathway BSID Mismatch repair
disease MESH renal cancers
disease DOID Syndrome
disease MESH Syndrome
drug DRUGBANK Etoperidone
disease MESH multiple
gene UNIPROT CORIN
gene UNIPROT CRNKL1
gene UNIPROT JTB
gene UNIPROT NR1I2
gene UNIPROT PAGE3
gene UNIPROT SGSM3
gene UNIPROT AATF
gene UNIPROT RASA1
gene UNIPROT RGS6
gene UNIPROT PAGE2
gene UNIPROT PDC
gene UNIPROT USH2A
disease DOID Lynch Syndrome
disease MESH Lynch Syndrome
disease MESH Multi

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