Therapeutic Potential of the Microbiome in the Treatment of Neuropsychiatric Disorders.

Therapeutic Potential of the Microbiome in the Treatment of Neuropsychiatric Disorders.

Publication date: Jan 31, 2019

The search for rational treatment of neuropsychiatric disorders began with the discovery of chlorpromazine in 1951 and continues to evolve. Day by day, new details of the intestinal microbiota⁻brain axis are coming to light. As the role of microbiota in the etiopathogenesis of neuropsychiatric disorders is more clearly understood, microbiota-based (or as we propose, “fecomodulation”) treatment options are increasingly discussed in the context of treatment. Although their history dates back to ancient times, the importance of psychobiotics and fecal microbiota transplantation (FMT) has only recently been recognized. Despite there being few preclinical and clinical studies, the evidence gathered to this point suggests that consideration of the microbiome in the treatment of neuropsychiatric disorders represents an area of significant therapeutic potential. It is increasingly hoped that such treatment options will be more reliable in terms of their side effects, cost, and ease of implementation. However, there remains much to be researched. Questions will be answered through germ-free animal experiments and randomized controlled trials. In this article, the therapeutic potential of microbiota-based options in the treatment of neuropsychiatric disorders is discussed in light of recent research.

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Evrensel, A., “Onen “Unsalver, B., and Ceylan, M.E. Therapeutic Potential of the Microbiome in the Treatment of Neuropsychiatric Disorders. 03391. 2019 Med Sci (Basel) (7):2.

Concepts Keywords
Basel Transplantation
Chlorpromazine Prebiotic
Microbiome Fecal microbiota transplant
Microbiota Dysbiosis
Neuropsychiatric Gut flora
Randomized Controlled Trials Firmicutes
Sci Environmental microbiology
Digestive system
Medicine
Medical specialties
Branches of biology
Bacteriology

Semantics

Type Source Name
gene UNIPROT TUBE1
disease DOID Clostridium difficile colitis
gene UNIPROT FGD1
gene UNIPROT EHD1
gene UNIPROT NSMAF
gene UNIPROT CNTRL
disease DOID major depressive disorder
disease MESH major depressive disorder
drug DRUGBANK (S)-Des-Me-Ampa
disease DOID candidiasis
disease MESH candidiasis
gene UNIPROT DES
drug DRUGBANK Diethylstilbestrol
gene UNIPROT UBXN11
pathway BSID Translation
gene UNIPROT EGR3
gene UNIPROT FOXL2
gene UNIPROT CNTN3
disease MESH neurological disorders
gene UNIPROT SERPINB1
gene UNIPROT FOXG1
disease MESH infarction
pathway BSID Gastric acid secretion
drug DRUGBANK Sertraline
disease DOID epilepsy
disease MESH epilepsy
drug DRUGBANK Desipramine
gene UNIPROT NTRK2
gene UNIPROT APPL1
gene UNIPROT SPG21
gene UNIPROT SPACA9
gene UNIPROT CHAMP1
gene UNIPROT CAMP
drug DRUGBANK Cyclic Adenosine Monophosphate
drug DRUGBANK Efavirenz
gene UNIPROT DUOXA1
gene UNIPROT TLR2
disease DOID necrotizing enterocolitis
disease MESH necrotizing enterocolitis
disease DOID irritable bowel syndrome
disease MESH irritable bowel syndrome
disease MESH autism spectrum disorders
gene UNIPROT TNIP1
disease MESH psychological stress
gene UNIPROT CD40LG
disease MESH Paleo Diet
gene UNIPROT INTU
disease MESH mental disorders
gene UNIPROT MBNL1
disease MESH infection
disease DOID Hay fever
disease MESH Hay fever
drug DRUGBANK Lactic Acid
disease DOID melancholia
disease MESH melancholia
gene UNIPROT IZUMO1
gene UNIPROT IDUA
gene UNIPROT OXCT2
drug DRUGBANK Guanosine
gene UNIPROT ACTA1
drug DRUGBANK Methyl isocyanate
disease MESH separation
disease MESH weight gain
drug DRUGBANK Olanzapine
gene UNIPROT TP53INP2
gene UNIPROT OPRD1
gene UNIPROT NAA50
disease DOID AIDS
disease MESH AIDS
disease MESH community
pathway BSID Quorum sensing
gene UNIPROT PROC
disease MESH inflammation
gene UNIPROT BRD2
disease DOID schizophrenia
disease MESH schizophrenia
drug DRUGBANK L-Tryptophan
disease MESH tryptophan
disease MESH tumor
gene UNIPROT TNF
gene UNIPROT IL6
gene UNIPROT IL1A
gene UNIPROT IL10
gene UNIPROT SLC5A8
gene UNIPROT CD79A
gene UNIPROT USH1G
gene UNIPROT IRF6
drug DRUGBANK Flunarizine
disease MESH death
disease DOID colitis
disease MESH colitis
disease MESH enteritis
disease DOID peritonitis
disease MESH peritonitis
disease MESH bleeding
disease MESH complications
disease DOID constipation
disease DOID diarrhea
gene UNIPROT GAST
gene UNIPROT PAGR1
gene UNIPROT GALNS
disease DOID ulcerative colitis
disease MESH ulcerative colitis
disease MESH Clostridium difficile infection
drug DRUGBANK Vancomycin
gene UNIPROT COL9A3
gene UNIPROT COMP
gene UNIPROT COL9A1
gene UNIPROT COL9A2
gene UNIPROT SCN8A
disease MESH psychosis
pathway BSID Tuberculosis
disease DOID tuberculosis
disease MESH tuberculosis
drug DRUGBANK Iproniazid
drug DRUGBANK Hydrocortisone
disease DOID syndrome
disease MESH syndrome
drug DRUGBANK Fluoxetine
drug DRUGBANK Citalopram
drug DRUGBANK gamma-Aminobutyric acid
drug DRUGBANK Dopamine
drug DRUGBANK Norepinephrine
gene UNIPROT HTR1A
drug DRUGBANK Serotonin
pathway BSID Free fatty acid receptors
drug DRUGBANK Butyric Acid
pathway BSID Fatty acids
disease MESH abnormalities
drug DRUGBANK Ketamine
gene UNIPROT BDNF
pathway BSID Brain derived neurotrophic factor
disease DOID anxiety
disease MESH anxiety
gene UNIPROT TLR4
disease MESH PRRs
pathway BSID Metabolism
gene UNIPROT DNMT1
gene UNIPROT CD69
gene UNIPROT CD5L
gene UNIPROT FASTK
disease MESH habits
disease DOID autism
disease MESH autism
drug DRUGBANK Nonoxynol-9
disease MESH allergies
drug DRUGBANK Spinosad
drug DRUGBANK Minocycline
disease MESH depression
gene UNIPROT LARGE1
pathway BSID Immune System
gene UNIPROT SMIM10L2A
gene UNIPROT SMIM10L2B
disease MESH dysbiosis
gene UNIPROT ETV6
drug DRUGBANK Coenzyme M
gene UNIPROT CAD
gene UNIPROT DFFB
gene UNIPROT ACOD1
gene UNIPROT CTBP1
gene UNIPROT TNFSF14
drug DRUGBANK Chlorpromazine

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